IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy
Ai, Ding1,4,5; Pang, Wei1; Li, Nan1; Xu, Ming2,3; Jones, Paul D.4,5,7; Yang, Jun4,5; Zhang, Youyi2,3; Chiamvimonvat, Nipavan6; Shyy, John Y. -J.8; Hammock, Bruce D.4,5; Zhu, Yi1
关键词epoxyeicosatrienoic acid cardiomyocyte activator protein 1
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2009-01-13
DOI10.1073/pnas.0811022106
106期:2页:564-569
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SENSITIVE K+ CHANNELS ; INNER MITOCHONDRIAL-MEMBRANE ; REGULATED KINASE PATHWAY ; JUN NH2-TERMINAL KINASE ; PRESSURE-OVERLOAD ; BLOOD-PRESSURE ; HEART-FAILURE ; ATP CHANNELS ; IN-VITRO ; HYPERTENSION
英文摘要

Pathophysiological cardiac hypertrophy is one of the most common causes of heart failure. Epoxyeicosatrienoic acids, hydrolyzed and degraded by soluble epoxide hydrolase (sEH), can function as endothelium-derived hyperpolarizing factors to induce dilation of coronary arteries and thus are cardioprotective. In this study, we investigated the role of sEH in two rodent models of angiotensin II (Ang II)-induced cardiac hypertrophy. The protein level of sEH was elevated in the heart of both spontaneously hypertensive rats and Ang II-infused Wistar rats. Blocking the Ang II type 1 receptor with losartan could abolish this induction. Administration of a potent sEH inhibitor (sEHI) prevented the pathogenesis of the Ang II-induced hypertrophy, as demonstrated by decreased left-ventricular hypertrophy assessed by echocardiography, reduced cardiomyocyte size, and attenuated expression of hypertrophy markers, including atrial natriuretic factor and beta-myosin heavy chain. Because sEH elevation was not observed in exercise-or norepinephrine-induced hypertrophy, the sEH induction was closely associated with Ang II-induced hypertrophy. In vitro, Ang II upregulated sEH and hypertrophy markers in neonatal cardiomyocytes isolated from rat and mouse. Expression of these marker genes was elevated with adenovirus-mediated sEH overexpression but decreased with sEHI treatment. These results were supported by studies in neonatal cardiomyocytes from sEH(-/-) mice. Our results suggest that sEH is specifically upregulated by Ang II, which directly mediates Ang II-induced cardiac hypertrophy. Thus, pharmacological inhibition of sEH would be a useful approach to prevent and treat Ang II-induced cardiac hypertrophy.

语种英语
WOS记录号WOS:000262804000039
项目编号30570713 ; 30630032 ; R37 ; ES02710 ; P42 ; ES04699 ; ES05707 ; P42 ; ES04699 ; HL 85727 ; F32 HL078096
资助机构National Natural Science Foundation of China ; Major National Basic Research ; National Institute of Environmental Health Sciences ; National Institutes of Health ; National Heart, Lung, and Blood Institute Ruth L. Kirschstein National Service
引用统计
被引频次:102[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59726
专题北京大学第三临床医学院_心血管内科
作者单位1.Int Flavors & Fragrances Inc, Union Beach, NJ 07735 USA
2.Peking Univ, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China
5.Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA
6.Univ Calif Davis, Canc Res Ctr, Davis, CA 95616 USA
7.Univ Calif Davis, Univ Calif Med Ctr, Dept Cardiovasc Med, Davis, CA 95616 USA
8.Univ Calif Riverside, Div Biomed Sci, Riverside, CA 92521 USA
推荐引用方式
GB/T 7714
Ai, Ding,Pang, Wei,Li, Nan,et al. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(2):564-569.
APA Ai, Ding.,Pang, Wei.,Li, Nan.,Xu, Ming.,Jones, Paul D..,...&Zhu, Yi.(2009).Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(2),564-569.
MLA Ai, Ding,et al."Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.2(2009):564-569.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ai, Ding]的文章
[Pang, Wei]的文章
[Li, Nan]的文章
百度学术
百度学术中相似的文章
[Ai, Ding]的文章
[Pang, Wei]的文章
[Li, Nan]的文章
必应学术
必应学术中相似的文章
[Ai, Ding]的文章
[Pang, Wei]的文章
[Li, Nan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。