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Lanthanum chloride bidirectionally influences calcification in bovine vascular smooth muscle cells
Zhao, Wen-Hua2; Gou, Bao-Di1; Zhang, Tian-Lan1; Wang, Kui1
关键词VASCULAR SMOOTH MUSCLE CELLS LANTHANUM CHLORIDE CALCIUM PHOSPHATE DEPOSITION CALCIUM-SENSING RECEPTOR APOPTOSIS
刊名JOURNAL OF CELLULAR BIOCHEMISTRY
2012-05-01
DOI10.1002/jcb.24049
113期:5页:1776-1786
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]CALCIUM-SENSING RECEPTOR ; NEPHROGENIC SYSTEMIC FIBROSIS ; PHOSPHATE CRYSTALS ; ATHEROSCLEROSIS ; GADOLINIUM ; CARBONATE ; DEPOSITION ; APOPTOSIS ; CYTOTOXICITY ; MECHANISMS
英文摘要

Vascular calcification (VC) is frequent prevalence in patients with chronic kidney disease (CKD) and atherosclerosis. Lanthanum carbonate is used as an orally administered phosphate-binding agent to reduce the gastrointestinal absorption of phosphate and ameliorate VC in advanced CKD. In this study, we used bovine vascular smooth muscle cells as a model VC in vitro and studied the effects of lanthanum chloride on calcium deposition. Exposure of cells to LaCl3 at the concentration of 0.1 mu M suppressed the beta-glycerophosphate-induced alkaline phosphatase activity and calcium deposition. Furthermore, LaCl3 upregulated the beta-glycerophosphate-suppressed expression of calcium-sensing receptor. In contrast to the inhibitory effect of LaCl3 on calcium deposition, higher level lanthanum (50 mu M) was found to promote immediately precipitation of calcium phosphate in cell culture medium. At this concentration, LaCl3 was found to induce cell apoptosis which involves caspases-9 and -3. These data indicate that the promotory effect of LaCl3 on calcium deposition is likely mediated by induction of apoptosis. Our in vitro findings do suggest that, in the context of raised lanthanum, greater attention should be paid to potential toxic effects associated to the use of lanthanide-based drugs. J. Cell. Biochem. 113: 17761786, 2012. (C) 2011 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000301524900033
项目编号20637010 ; 21071007
资助机构National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59730
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Capital Med Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100069, Peoples R China
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Zhao, Wen-Hua,Gou, Bao-Di,Zhang, Tian-Lan,et al. Lanthanum chloride bidirectionally influences calcification in bovine vascular smooth muscle cells[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2012,113(5):1776-1786.
APA Zhao, Wen-Hua,Gou, Bao-Di,Zhang, Tian-Lan,&Wang, Kui.(2012).Lanthanum chloride bidirectionally influences calcification in bovine vascular smooth muscle cells.JOURNAL OF CELLULAR BIOCHEMISTRY,113(5),1776-1786.
MLA Zhao, Wen-Hua,et al."Lanthanum chloride bidirectionally influences calcification in bovine vascular smooth muscle cells".JOURNAL OF CELLULAR BIOCHEMISTRY 113.5(2012):1776-1786.
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