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学科主题: 药学
题名:
Sequence and modified group analysis on C-terminal modified analogs of endomorphin-2 using electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometer
作者: Zhu ChuanJun2; Hu ChangFeng2; Shao Xuan1,2; Yao JinLong1; Wang ChangLin1; Wang Rui1; Cui YuXin2
关键词: endomorphin-2 ; opioid peptide analogs ; ESI ; FT-ICR MS ; McLafferty rearrangement
刊名: SCIENCE IN CHINA SERIES B-CHEMISTRY
发表日期: 2008
DOI: 10.1007/s11426-007-0123-8
卷: 51, 期:1, 页:41-45
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: AMINO-ACID-SEQUENCE ; ANTINOCICEPTIVE ACTIVITY ; MORPHICEPTIN ANALOGS ; PEPTIDES ; RECEPTOR ; POSITION
英文摘要:

In this paper, a series of C-terminal modified analogs of endomorphin-2 is investigated using ESI-FT-ICR-MS. Some b, y", a, and internal ions are found in the CID spectra and slight mass differences between the calculated and observed results are obtained. Moreover, if the C-terminal modified group is t-butyloxy, it can lose butene through McLafferty rearrangement. FT-ICR MS shows its power in peptide sequencing successfully helping us obtain the structure of peptide analogs.

语种: 英语
WOS记录号: WOS:000251972200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59733
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Zhu ChuanJun,Hu ChangFeng,Shao Xuan,et al. Sequence and modified group analysis on C-terminal modified analogs of endomorphin-2 using electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometer[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2008,51(1):41-45.
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