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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Partially Matched Related Donor Transplantation Can Achieve Outcomes Comparable with Unrelated Donor Transplantation for Patients with Hematologic Malignancies
作者: Huang Xiao-Jun; Xu Lan-Ping; Liu Kai-Yan; Liu Dai-Hong; Wang Yu; Chen Huan; Chen Yu-Hong; Han Wei; Wang Jing-Zhi; Chen Yao; Zhang Xiao-Hui; Shi Hong-Xia; Wang Feng-Rong; Tang Fei-Fei
刊名: CLINICAL CANCER RESEARCH
发表日期: 2009-07-15
DOI: 10.1158/1078-0432.CCR-09-0691
卷: 15, 期:14, 页:4777-4783
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; CHRONIC MYELOID-LEUKEMIA ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; COLONY-STIMULATING FACTOR ; LYMPHOCYTE INFUSION ; RELAPSE ; DEPLETION ; IMPACT ; GRAFT
英文摘要:

Purpose: The study aimed to compare the outcomes of patients undergoing hematopoietic stem cell transplantation (HSCT) from partially matched related donors (PMRD) and unrelated donors (URD) for hematologic malignancies without the use of in vitro T cell depletion.

Experimental Design: HSCT was done on 297 consecutive patients from URDs (n = 78) and PMRDs (n = 219) during the same time period. Incidences of graft-versus-host disease (GVHD), relapse, nonrelapse mortality, overall survival, and leukemia-free survival between the PMRD and URD groups were compared.

Results: All patients achieved full engraftment. The cumct65ulative incidences of grades 11 to IV acute GVHD in the PMRD and URD cohorts were 47% [95% confidence interval (95% CI), 33-62%] versus 31% (Cl, 20-42%; P = 0.033), with a relative risk of 1.72 (95% Cl, 1.01-2.94; P = 0.046).The incidence of chronic GVHD did not differ significantly between the two cohorts (P = 0.17). The 2-year incidences of nonrelapse mortality and relapse were 20% (Cl, 15-26%) versus 18% (Cl, 10-27%), with P = 0.98, and 12% (Cl, 8-16%) versus 18% (Cl, 10-27%), with P = 0.12, for the PMRD versus the URD cohort, respectively. The 4-year overall survival and leukemia-free survival were 74% (Cl, 67-80%) versus 74% (Cl, 62-85%), with P = 0.98, and 67% (Cl, 59-75%) versus 61% (Cl, 47-74%), with P = 0.74, respectively.

Conclusions: Our comparisons show that every major end point, including relapse, nonrelapse mortality, overall survival, and leukemia-free survival, was comparable between the PMRD and the URD groups.

语种: 英语
所属项目编号: 30725038 ; 2006AA02Z4A0 ; IRT 0702 ; 2006-1010
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-tech Research and Development Program of China ; Program for Innovative Research Team in University ; Scientific Research Fund for Capital Medicine Development ; Ministry of Health of China
WOS记录号: WOS:000268908400033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59746
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Huang Xiao-Jun,Xu Lan-Ping,Liu Kai-Yan,et al. Partially Matched Related Donor Transplantation Can Achieve Outcomes Comparable with Unrelated Donor Transplantation for Patients with Hematologic Malignancies[J]. CLINICAL CANCER RESEARCH,2009,15(14):4777-4783.
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