IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科
学科主题临床医学
Expression of Delta DNMT3B variants and its association with promoter methylation of p16 and RASSF1A in primary non-small cell lung cancer
Wang, Jie; Walsh, Garret; Liu, Diane D.; Lee, J. Jack; Mao, Li
刊名CANCER RESEARCH
2006-09-01
DOI10.1158/0008-5472.CAN-06-2031
66期:17页:8361-8366
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]DNA METHYLTRANSFERASES ; PWWP DOMAIN ; DNMT3B ; OVEREXPRESSION ; 3B ; HYPERMETHYLATION ; FAMILY ; TUMORS ; GENES ; 3A
英文摘要

Despite the role of DNMT3B in de novo DNA methylation, a correlation between DNMT3B expression and promoter DNA methylation has not being established in tumors. We recently reported Delta DNMT3B, a subfamily of DNMT3B, with seven variants, as the predominant expression forms in non-small cell lung cancer (NSCLC). We hypothesized that expression of the Delta DNMT3B variants plays a role in promoter methylation formation during lung tumorigenesis. Expression of seven Delta DNMT3B variants was measured in 119 NSCLCs and the corresponding normal lungs using reverse transcription-PCR. The expression patterns of Delta DNMT3B variants were analyzed with the status of p16 and RASSF1A promoter methylation in the tumors as well as in patients′ clinical variables, including outcomes. Expression of Delta DNMT3B variants was detected in 94 of 119 (80%) tumors but in only 22 (18%) of the corresponding normal lungs (P < 0.0001). Delta DNMT3B1, Delta DNMT3B2, and Delta DNMT3B4 were the most frequently detected transcripts in the tumors (62%, 76%, and 46%, respectively). The expression of Delta DNMT3B variants was associated with p16 and RASSF1A promoter methylation in the tumors, but the strongest association was between Delta DNMT3B4 and RASSF1A. Forty-two of 46 (91%) tumors with RASSF1A promoter methylation expressed Delta DNMT3B4 compared with only 13 of 73 (18%) tumors without the promoter methylation (P < 0.0001). Strong associations were also observed between expression of the variants in the tumors and in patients′ clinical outcomes. Expression of Delta DNMT3B variants is common in NSCLC and may play an important role in the development of promoter methylation.

语种英语
WOS记录号WOS:000240329400009
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59748
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.Univ Texas, MD Anderson Canc Ctr, Mol Biol Lab, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA
2.Univ Texas, MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA
3.Univ Texas, MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA
4.Beijing Univ, Sch Oncol, Beijing Canc Hosp, Dept Oncol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jie,Walsh, Garret,Liu, Diane D.,et al. Expression of Delta DNMT3B variants and its association with promoter methylation of p16 and RASSF1A in primary non-small cell lung cancer[J]. CANCER RESEARCH,2006,66(17):8361-8366.
APA Wang, Jie,Walsh, Garret,Liu, Diane D.,Lee, J. Jack,&Mao, Li.(2006).Expression of Delta DNMT3B variants and its association with promoter methylation of p16 and RASSF1A in primary non-small cell lung cancer.CANCER RESEARCH,66(17),8361-8366.
MLA Wang, Jie,et al."Expression of Delta DNMT3B variants and its association with promoter methylation of p16 and RASSF1A in primary non-small cell lung cancer".CANCER RESEARCH 66.17(2006):8361-8366.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Jie]的文章
[Walsh, Garret]的文章
[Liu, Diane D.]的文章
百度学术
百度学术中相似的文章
[Wang, Jie]的文章
[Walsh, Garret]的文章
[Liu, Diane D.]的文章
必应学术
必应学术中相似的文章
[Wang, Jie]的文章
[Walsh, Garret]的文章
[Liu, Diane D.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。