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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸外科  > 期刊论文
学科主题: 临床医学
题名:
Reconstruction of Large Tracheal Defects in a Canine Model: Lessons Learned
作者: Zang, Mengqing1; Chen, Keneng2; Yu, Peirong3
关键词: Tracheal reconstruction ; free flaps ; dog model
刊名: JOURNAL OF RECONSTRUCTIVE MICROSURGERY
发表日期: 2010-07-01
DOI: 10.1055/s-0030-1249605
卷: 26, 期:6, 页:391-399
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: PROSTHESIS ; GRAFTS ; FLAP
英文摘要:

Tracheal reconstruction remains a major clinical problem owing to the need for rigid support and a lining to maintain a patent lumen. The purpose of this study was to investigate the feasibility of microsurgical tracheal reconstruction in large animals. Two-stage tracheal reconstruction was attempted in six dogs and single-stage reconstruction in eight dogs. In the first-stage prelamination, tubular prosthetic material was lined with an abdominal fascial flap with skin grafting and covered with a rectus abdominis muscle flap. The construct was buried under the abdominal skin for 3 weeks, and then microsurgical tracheal reconstruction for a 6-cm-long defect was performed. Prosthetic materials tested were PolyMax mesh (Synthes, Paoli, PA), polytetrafluoroethylene graft, and polytetrafluoroethylene graft stented with PolyMax mesh. In single-stage reconstruction, supporting materials were lined with an abdominal fasciocutaneous flap for microsurgical reconstruction. Supporting materials included polytetrafluoroethylene graft stented with PolyMax mesh, polypropylene mesh with ring support, and cross-linked urinary bladder matrix. First-stage prelamination failed in three dogs because of prosthetic collapse and infection. Second-stage reconstruction was performed in the other three dogs, but fatal complications occurred in the immediate postoperative period. In single-stage reconstruction, prosthetic failure remained the major problem, resulting in early deaths. Air leakage and difficulties in providing postoperative care for dogs were other factors limiting longterm survival. We encountered significant prosthetic failures and difficulties in postoperative care in dog tracheal reconstruction. Further research is needed to develop better supporting materials. Alternative animal models may be sought to minimize complications.

语种: 英语
项目资助者: University of Texas M. D. Anderson Cancer Center, Houston, TX ; Anesthesiology Fund for Workshops
WOS记录号: WOS:000279057300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59750
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Beijing Canc Hosp, Dept Thorac Surg, Beijing, Peoples R China
2.Peking Union Med Coll, Plast Surg Hosp, Beijing 100021, Peoples R China
3.Univ Texas MD Anderson Canc Ctr, Dept Plast Surg, Unit 443, Houston, TX 77030 USA

Recommended Citation:
Zang, Mengqing,Chen, Keneng,Yu, Peirong. Reconstruction of Large Tracheal Defects in a Canine Model: Lessons Learned[J]. JOURNAL OF RECONSTRUCTIVE MICROSURGERY,2010,26(6):391-399.
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