IR@PKUHSC  > 北京大学深圳医院  > 皮肤性病科
学科主题临床医学
Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis
Yu, B.1,2; Shao, Y.1,2; Zhang, J.1,2; Dong, X. L.1; Liu, W. L.1; Yang, H.1,3; Liu, L.1; Li, M. H.1; Yue, C. F.1; Fang, Z. Y.1; Zhang, C.1; Hu, X. P.2; Chen, B. C.2; Wu, Q.1; Chen, Y. W.; Zhang, W.; Wan, J.1,4
关键词atopic dermatitis histamine receptor H4 HRH4 single nucleotide polymorphism
刊名BRITISH JOURNAL OF DERMATOLOGY
2010-05-01
DOI10.1111/j.1365-2133.2010.09675.x
162期:5页:1038-1043
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]H-4 RECEPTOR ; SUSCEPTIBILITY GENES ; MEDIATES CHEMOTAXIS ; FILAGGRIN ; CELLS ; LOCI ; ALLERGY
英文摘要

P>Background

Atopic dermatitis (AD) is a chronic skin disease affecting more than 15% of children and 2% of adults. A strong connection between genetic factors and AD has been described for a long time. Histamine receptor H4 (HRH4) has been shown to be related to different kinds of allergic and autoimmune disorders. However, an association between HRH4 and AD has not yet been reported.

Objectives

To examine a possible association between HRH4 and AD.

Methods

Genomic DNA from 301 patients with AD and 313 healthy controls was extracted and three exons of HRH4 were sequenced.

Results

We found three new single nucleotide polymorphisms (SNPs) in HRH4 which were significantly associated with AD: ss142022671 [odds ratio (OR) 1 center dot 87, 95% confidence interval (CI) 1 center dot 24-2 center dot 81; P = 0 center dot 002], ss142022677 (OR 4 center dot 40, 95% CI 2 center dot 42-8 center dot 00; P = 1 center dot 5 x 10-7) and ss142022679 (OR 4 center dot 26, 95% CI 2 center dot 38-7 center dot 61; P = 1 center dot 3 x 10-7). The SNPs ss142022677 and ss142022679 were found to be in strong linkage disequilibrium (D′ = 0 center dot 98; r2 = 0 center dot 92). Two-SNP haplotype analysis (ss142022677 and ss142022679) showed that the major AA haplotype was protective against AD (OR 0 center dot 22, 95% CI 0 center dot 12-0 center dot 40; P = 3 center dot 1 x 10-8) and the minor TT haplotype was significantly associated with AD (OR 4 center dot 13, 95% CI 2 center dot 27-7 center dot 54; P = 6 center dot 6 x 10-7). In addition, in a three-SNP haplotype analysis (ss142022671, ss142022677 and ss142022679), the major TAA haplotype was protective against AD (OR 0 center dot 46, 95% CI 0 center dot 31-0 center dot 69; P = 0 center dot 0001), while the complementary ATT haplotype was found to be significantly associated with AD (OR 3 center dot 81, 95% CI 2 center dot 03-7 center dot 14; P = 8 center dot 3 x 10-6).

Conclusions

Polymorphisms of ss142022671, ss142022677 and ss142022679 in HRH4 are associated with AD.

语种英语
WOS记录号WOS:000276853600013
资助机构Shenzhen-Hong Kong Technological Cooperation
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59754
专题北京大学深圳医院_皮肤性病科
北京大学第二临床医学院_呼吸科
北京大学口腔医学院_材料检测中心
北京大学临床肿瘤学院_护理部
作者单位1.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen 518036, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Yu, B.,Shao, Y.,Zhang, J.,et al. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis[J]. BRITISH JOURNAL OF DERMATOLOGY,2010,162(5):1038-1043.
APA Yu, B..,Shao, Y..,Zhang, J..,Dong, X. L..,Liu, W. L..,...&Wan, J..(2010).Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis.BRITISH JOURNAL OF DERMATOLOGY,162(5),1038-1043.
MLA Yu, B.,et al."Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis".BRITISH JOURNAL OF DERMATOLOGY 162.5(2010):1038-1043.
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