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学科主题: 基础医学
题名:
LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma
作者: Yang, Hua1; Xiong, Fu Xia1; Lin, Ming1; Yang, Yu2; Nie, Xiu3; Zhou, Rou Li1
关键词: Lysosomal protein transmembrane 4 beta ; Immunohistochemistry ; HCC ; Recurrence ; Survival
刊名: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
发表日期: 2010-02-01
DOI: 10.1007/s00432-009-0659-4
卷: 136, 期:2, 页:275-281
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MULTIDRUG-RESISTANCE ; MEMBRANE-PROTEIN ; EXPRESSION ; SURVIVAL ; INVASION ; MARKER ; KINASE ; AKT
英文摘要:

Lysosomal protein transmembrane 4 beta-35 (LAPTM4B-35) is a tetra-transmembrane glycoprotein that is abundantly localized on membrane-bound organelles including endosomes and lysosomes, and promotes cell proliferation and tumorigenesis through regulation of cell cycle and signaling pathways. The aim of the present study is to determine the potential clinical implications of LAPTM4B-35 expression in hepatocellular carcinoma (HCC).

Immunohistochemistry assay was used to determine the expression of LAPTM4B-35 protein in normal and HCC tissues from 71 patients. The correlations of LAPTM4B-35 expression with clinicopathological parameters, including gender, age, background liver, viral status, tumor size, portal vein invasion, histopathological differentiation, serum AFP level, TNM staging and recurrence of HCC were assessed by Chi-squared test. Patient survival and their differences were determined by Kaplan-Meier method and log-rank test. Cox regression (Proportional hazard model) was adopted for multivariate analysis of prognostic factors.

LAPTM4B-35 immunoreactivity was negative or low in normal liver tissues, but high in HCC tissues (51/71, 71.8%). The overexpression of LAPTM4B-35 was significantly associated with recurrence, TNM staging and portal vein invasion of HCC. Patients with high LAPTM4B-35 expression had significantly poorer overall survival (OS) and disease-free survival (DFS) (both P < 0.001) when compared with patients with the low expression of LAPTM4B-35. On multivariate analysis, LAPTM4B-35 expression was found to be an independent prognostic factor for OS and DFS (P = 0.018 and P = 0.001, respectively).

LAPTM4B-35 expression showed a strong association with the potencies of recurrence and metastasis and progression of HCC, and that may be applied as a novel marker for the prediction of recurrence and metastasis potency of HCC, and helpful for improving the diagnosis, prognosis and treatment of HCC.

语种: 英语
WOS记录号: WOS:000273033100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59759
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Childrens Natl Med Ctr, Ctr Mol Physiol Res, Washington, DC 20010 USA
3.Huazhong Univ Sci & Technol, Dept Pathol, Union Hosp Affiliated, Tongji Med Coll, Wuhan 430022, Peoples R China

Recommended Citation:
Yang, Hua,Xiong, Fu Xia,Lin, Ming,et al. LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2010,136(2):275-281.
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