北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
CXCL5 knockdown expression inhibits human bladder cancer T24 cells proliferation and migration
作者: Zheng, Jiajia1; Zhu, Xi2; Zhang, Jie1
关键词: CXCL5 ; Bladder cancer ; T24 cells ; Cells proliferation and migration
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-03-28
DOI: 10.1016/j.bbrc.2014.01.172
卷: 446, 期:1, 页:18-24
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: PROSTATE-CANCER ; MESENCHYMAL TRANSITION ; SIGNALING PATHWAY ; GENE-EXPRESSION ; E-CADHERIN ; PANCREATIC-CANCER ; POOR-PROGNOSIS ; PEPTIDE ENA-78 ; IN-VIVO ; PROGRESSION
英文摘要:

CXCL5 (epithelial neutrophil activating peptide-78) which acts as a potent chemoattractant and activator of neutrophil function was reported to play a multifaceted role in tumorigenesis. To investigate the role of CXCL5 in bladder cancer progression, we examined the CXCL5 expression in bladder cancer tissues by real-time PCR and Western blot, additionally, we used shRNA-mediated silencing to generate stable CXCL5 silenced bladder cancer 124 cells and defined its biological functions. Our results demonstrated that mRNA and protein of CXCL5 is increased in human bladder tumor tissues and cell lines, downregulation of CXCL5 in T24 cells resulted in significantly decreased cell proliferation, migration and increased cell apoptosis in vitro through Snail, PI3K-AKT and ERK1/2 signaling pathways. These data suggest that CXCL5 is critical for bladder tumor growth and progression, it may represent a potential application in cancer diagnosis and therapy. (c) 2014 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000334654900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59760
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing, Peoples R China

Recommended Citation:
Zheng, Jiajia,Zhu, Xi,Zhang, Jie. CXCL5 knockdown expression inhibits human bladder cancer T24 cells proliferation and migration[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,446(1):18-24.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zheng, Jiajia]'s Articles
[Zhu, Xi]'s Articles
[Zhang, Jie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zheng, Jiajia]‘s Articles
[Zhu, Xi]‘s Articles
[Zhang, Jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace