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A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population
Liu, Haochen1; Zhang, Jin1; Song, Shujuan2; Zhao, Hongshan2,3; Han, Dong1; Feng, Hailan1
关键词case-control study non-syndromic hypodontia single nucleotide polymorphism tooth agenesis
刊名EUROPEAN JOURNAL OF ORAL SCIENCES
2012-10-01
DOI10.1111/j.1600-0722.2012.00986.x
120期:5页:378-385
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者Beijing Natural Science Foundation ; National Natural Science Foundation ; Capital Medical Developing Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation ; Capital Medical Developing Foundation
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]ONYCHO-DERMAL DYSPLASIA ; ECTODERMAL DYSPLASIA ; AGENESIS ; MUTATION ; WNT10A ; PAX9 ; MSX1 ; GLI3
英文摘要

Hypodontia is one of the most common anomalies of human dentition. Recent genetic studies provide information on a number of genes related to both syndromic and non-syndromic forms of hypodontia. Fifty putative single nucleotide polymorphisms (SNPs) in 20 genes that play important roles in tooth development were selected, and a casecontrol study was conducted in 273 subjects with hypodontia (cases) and 200 subjects without hypodontia (controls). DNA was obtained from samples of whole blood or saliva. Genotyping was performed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS). A significant difference was observed, between subjects with non-syndromic hypodontia and controls, in the allele and genotype frequencies of two markers [rs929387 of GLI family zinc finger 3 (GLI3) and rs11001553 of Dickkopf-related protein 1 (DKK1)]. Similar results were observed in a subgroup analysis of test subjects (stratified by gender or missing tooth position). However, this analysis showed no significant difference in the haplotype distribution between the controls and the affected subjects. These data demonstrate an association between some SNPs in tooth development-associated genes and sporadic non-syndromic hypodontia in Chinese Han individuals. This information may provide further understanding of the molecular mechanisms of tooth agenesis. Furthermore, these genes can be regarded as candidates for mutation detection in individuals with tooth agenesis.

语种英语
所属项目编号7092113 ; 81070814 ; 2007-1005
资助者Beijing Natural Science Foundation ; National Natural Science Foundation ; Capital Medical Developing Foundation ; Beijing Natural Science Foundation ; National Natural Science Foundation ; Capital Medical Developing Foundation
WOS记录号WOS:000308929800002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59764
专题北京大学口腔医学院_口腔修复科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Genet, Beijing 100081, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Ctr Human Dis Genom, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Liu, Haochen,Zhang, Jin,Song, Shujuan,et al. A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population[J]. EUROPEAN JOURNAL OF ORAL SCIENCES,2012,120(5):378-385.
APA Liu, Haochen,Zhang, Jin,Song, Shujuan,Zhao, Hongshan,Han, Dong,&Feng, Hailan.(2012).A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population.EUROPEAN JOURNAL OF ORAL SCIENCES,120(5),378-385.
MLA Liu, Haochen,et al."A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population".EUROPEAN JOURNAL OF ORAL SCIENCES 120.5(2012):378-385.
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