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学科主题: 临床医学
题名:
Association between vitamin C deficiency and dialysis modalities
作者: Zhang, Kunying1,2,3; Dong, Jie1,2,3; Cheng, Xuyang1,2,3; Bai, Wenying4; Guo, Weiya5; Wu, Leiyun6; Zuo, Li1,2,3
关键词: haemodialysis ; peritoneal dialysis ; vitamin C deficiency
刊名: NEPHROLOGY
发表日期: 2012-07-01
DOI: 10.1111/j.1440-1797.2012.01595.x
卷: 17, 期:5, 页:452-457
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: AMBULATORY PERITONEAL-DIALYSIS ; CHRONIC-RENAL-FAILURE ; HEMODIALYSIS-PATIENTS ; OXIDATIVE STRESS ; ASCORBIC-ACID ; NUTRITIONAL ASSESSMENT ; PREALBUMIN ; SERUM ; PROTEIN ; HEMODIAFILTRATION
英文摘要:

Aim: We designed a cross-sectional study to investigate plasma vitamin C level in patients who underwent maintenance haemodialysis (MHD) and continuous ambulatory peritoneal dialysis (CAPD) to explore whether there is a difference in vitamin C deficiency between MHD patients and CAPD patients. Methods: This investigation included 382 dialysis patients without vitamin C supplement before the study. Demographic characteristics, laboratory tests, ascorbic acid and total plasma vitamin C level were measured. A linear regression model was built to explore the association between vitamin C deficiency and dialysis modalities after adjusting for age, dialysis vintage, gender, Charlson index, modality of dialysis and hsCRP. Results: The range of plasma vitamin C level was from 0.48 mu g/mL to 31.16 mu g/mL. 35.9% (n = 137) patients had severe vitamin C deficiency (<2 mu g/mL). Plasma vitamin C level was inversely associated with age and dialysis vintage. After age and dialysis vintage were adjusted, vitamin C deficiency was associated with MHD. R square for model fitting was relatively low, which implied that there were other vitamin C influencing factors not included in the model. Conclusions: Vitamin C deficiency is common in dialysis patients, especially in patients treated with MHD.

语种: 英语
WOS记录号: WOS:000305567300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59767
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Beijing Daxing Dist Peoples Hosp, Beijing, Peoples R China
2.Guangwai Hosp, Beijing, Peoples R China
3.Beijing 2 Hosp, Beijing, Peoples R China
4.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
5.Key Lab Renal Dis, Beijing, Peoples R China
6.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Kunying,Dong, Jie,Cheng, Xuyang,et al. Association between vitamin C deficiency and dialysis modalities[J]. NEPHROLOGY,2012,17(5):452-457.
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