北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学深圳医院  > 血液内科  > 期刊论文
学科主题: 临床医学
题名:
Adult Aggressive Natural Killer Cell Leukemia
作者: Zhang, Hongyu1; Meng, Qinxiang1; Yin, Weihua2; Xu, Lei1; Lie, Liping3
关键词: Aggressive natural killer cell leukemia ; Prognosis ; Bone marrow biopsy ; Immunohistochemistry
刊名: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
发表日期: 2013-07-01
卷: 346, 期:1, 页:56-63
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GRANULAR LYMPHOCYTE LEUKEMIA ; OF-THE-LITERATURE ; MALIGNANCIES ; GEMCITABINE ; LYMPHOMAS
英文摘要:

Introduction: Aggressive natural killer cell leukemia (ANKL) is a rare malignancy with a poor prognosis. Methods: Clinical and laboratory data of 20 patients with ANKL were collected retrospectively from a single medical center. Results: The prominent clinical complications included unexplained fever, interstitial pneumonia, hepatosplenomegaly, high level of lactate dehydrogenase and liver dysfunction. Both bone marrow (BM) biopsies and aspiration of 20 patients were morphologically and immunophenotypically evaluated. Only 2 patients with marked elevation of peripheral large granular lymphocytes had sufficient BM aspiration for flow cytometric immunophenotyping. However, 20 BM biopsies showed marked neoplastic cell infiltration, and immunohistochemistry highlighted patterns of neoplastic involvement. The neoplastic cells were mainly positive for CD2, CD56, CD3(C)(+) and Epstein-Barr virus (EBV)-encoded RNA. The plasma EBV-DNA test was positive in all cases, and complex cytogenetic abnormalities were identified in 8 cases. The median survival of the patients was 8 weeks, and the presence of liver dysfunction-induced jaundice (serum total bilirubin level > 34.2 mu mol/L) was identified as a risk factor for early death. Patients were generally resistant to chemotherapy, but notably, 3 patients demonstrated a marked response to gemcitabine with tolerable toxicities. Conclusions: These findings indicate that ANKL is a highly aggressive leukemia with a fulminating clinical course. A BM biopsy with immunohistochemistry and EBV-encoded RNA detection is mandatory for a rapid diagnosis of ANKL. Therefore, a careful evaluation and fully supported treatment plan should be conducted before chemotherapy is administered to patients with severe complications to improve the overall survival.

语种: 英语
WOS记录号: WOS:000330432900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59772
Appears in Collections:北京大学深圳医院_血液内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, ShenZhen Hosp, Dept Hematol, Shenzhen 518036, Peoples R China
2.Peking Univ, ShenZhen Hosp, Dept Pathol, Shenzhen 518036, Peoples R China
3.Peking Univ, ShenZhen Hosp, Dept Immunol, Shenzhen 518036, Peoples R China

Recommended Citation:
Zhang, Hongyu,Meng, Qinxiang,Yin, Weihua,et al. Adult Aggressive Natural Killer Cell Leukemia[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2013,346(1):56-63.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Hongyu]'s Articles
[Meng, Qinxiang]'s Articles
[Yin, Weihua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Hongyu]‘s Articles
[Meng, Qinxiang]‘s Articles
[Yin, Weihua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace