IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis
Xiang, Y; Ma, B; Li, T; Gao, JW; Yu, HM; Li, XJ
关键词neoplasms acetazolamide angiogenesis inhibitors CHIP28
刊名ACTA PHARMACOLOGICA SINICA
2004-06-01
25期:6页:812-816
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]TUMOR-METASTASIS ; XENOPUS OOCYTES ; WATER CHANNELS ; CANCER ; CELLS
英文摘要

AIM: To study effects of acetazolamide on aquaporin-1 (AQP(1)) protein expression and angiogenesis. METHODS: Establishing Lewis-lung-carcinoma model, the localization of AQP(1) in tumor tissues was investigated by immunohistochemical methods; The biological activity of acetazolamide was detected by endothelial cells proliferation test (MTT) assay and chorioallantoic membrane (CAM) vascular inhibition test. RESULTS: Immunohistochemical localization of AQP(1) in mice tumor was labeled in capillaries, post capillary venules endothelial cells. After being treated with acetazolamide, the number of capillaries and post capillary venules was significantly decreased in tumor tissue. Acetazolamide showed significant inhibitory effect on angiogenesis in CAM and endothelial cell proliferation. CONCLUSION: Acetazolamide might be identified and developed as one of potential lead compounds for a new therapeutic intervention in inhibiting cancer angiogenesis.

语种英语
WOS记录号WOS:000221833900018
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59775
Collection北京大学基础医学院_药理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Nanjing Univ, Inst Life Sci, Nanjing 210093, Peoples R China
3.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Xiang, Y,Ma, B,Li, T,et al. Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis[J]. ACTA PHARMACOLOGICA SINICA,2004,25(6):812-816.
APA Xiang, Y,Ma, B,Li, T,Gao, JW,Yu, HM,&Li, XJ.(2004).Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis.ACTA PHARMACOLOGICA SINICA,25(6),812-816.
MLA Xiang, Y,et al."Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis".ACTA PHARMACOLOGICA SINICA 25.6(2004):812-816.
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