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学科主题: 临床医学
题名:
Lower expression of ER-alpha 36 is associated with the development of endometrial hyperplasia in PCOS patients
作者: Lin, Sheng-Li1,2,3; Tu, Bin-Bin1,2,3; Du, Xiao-Guo1,2,3; Yan, Li-Ying1,2,3; Qiao, Jie1,2,3
关键词: Polycystic ovary syndrome ; Estrogen receptor-alpha 36 ; Endometrial hyperplasia
刊名: HISTOLOGY AND HISTOPATHOLOGY
发表日期: 2013-11-01
卷: 28, 期:11, 页:1491-1498
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: POLYCYSTIC-OVARY-SYNDROME ; ESTROGEN-RECEPTOR-ALPHA ; ER-ALPHA ; STEROID-RECEPTORS ; UNTREATED WOMEN ; MESSENGER-RNAS ; VARIANT ; CANCER ; RECEPTIVITY ; CARCINOMA
英文摘要:

Objective: To explore the expression change of ER-alpha 36 in endometria of PCOS patients. Methods: Proliferative endometria were collected and divided into three groups: CE group (n=30), proliferative endometria from control women; PCOSE group (n=30), proliferative endometria from PCOS patients; HPCOSE group (n=15), hyperplastic endometria from PCOS patients. The cellular localization of ER-alpha 36 and ER-alpha 66 was analyzed by immunohistochemistry, and expression of ER-alpha 36 and ER-alpha 66 was determined by immunohistochemistry and Real-Time Quantitative PCR. The correlation between serum hormone concentration and expression of ER-alpha 36 and ER-alpha 66 was analyzed. Results: ER-alpha 36 was localized on the cell surface, cytoplasm and nucleus of glandular epithelial cells of both CE and PCOSE groups, mainly on the cell surface, and ER-alpha 66 was localized on the nucleus. The protein and mRNA expression of ER-alpha 36 was decreased from CE, PCOSE to HPCOSE group, while expression of ER-alpha 66 showed no obvious difference among groups. The expression ratio of ER-alpha 36 to ER-alpha 66 of CE, PCOSE and HPCOSE group showed a decreasing tendency. The expression of ER-alpha 36 and its expressive ratio to ER-alpha 66 was negatively correlated with serum concentration of LH, LH/FSH, testosterone and androstenedione. Conclusions: Lower expression of ER-alpha 36 is associated with the development of endometrial hyperplasia in PCOS patients.

语种: 英语
所属项目编号: 30825038 ; 2007BAI04B04 ; 81200437
项目资助者: National Natural Science Funds for Distinguished Young Scholars ; National Scientific and Technical Supporting Programs ; Ministry of Science and Technology of China ; National Natural Science Funds of China for Young Scholars
WOS记录号: WOS:000325900000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59779
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China

Recommended Citation:
Lin, Sheng-Li,Tu, Bin-Bin,Du, Xiao-Guo,et al. Lower expression of ER-alpha 36 is associated with the development of endometrial hyperplasia in PCOS patients[J]. HISTOLOGY AND HISTOPATHOLOGY,2013,28(11):1491-1498.
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