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学科主题: 公共卫生
题名:
Molecular Epidemiology of Human Rhinovirus in Children with Acute Respiratory Diseases in Chongqing, China
作者: Lu, Qing-Bin1; Wo, Ying2; Wang, Li-Yuan2,3; Wang, Hong-Yu2,3; Huang, Dou-Dou2,3; Zhang, Xiao-Ai2; Liu, Wei2; Cao, Wu-Chun2
刊名: SCIENTIFIC REPORTS
发表日期: 2014-10-20
DOI: 10.1038/srep06686
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GENOTYPICALLY ASSIGNED TYPES ; SPECIES C ; HOSPITALIZED CHILDREN ; CLINICAL-FEATURES ; GENETIC DIVERSITY ; TRACT INFECTION ; HRV-C ; VIRUSES ; CLASSIFICATION ; RECOMBINATION
英文摘要:

Human rhinovirus-C (HRV-C) has been increasingly detected in patients with acute respiratory diseases (ARDs). Prolonged surveillance was performed on children with ARD to investigate the molecular epidemiology and clinical characteristics of HRV in Chongqing, China. Nasopharyngeal aspirates (NPA) were collected from hospitalized children with ARD during 2009-2012. HRV-C was genotyped by sequencing the VP4/VP2 coding region. Among the 1,567 NPAs obtained, 223 (14.2%) were HRV positive, and 75.3% of these 223 NPAs were co-infected with other viruses. HRV-A (54.7%) and HRV-C (39.9%) accounted for the majority of HRV infections. Logistic regression models demonstrated significant associations between HRV-A, HRV-C, and asthma attacks, as well as between HRV-C and wheezing. A phylogenetic tree showed that HRV-C2 was the predominant type of HRV-C, followed by HRV-C43, HRV-C1, and HRV-C17. Three novel genotypes were proposed on the basis of a low identity with the known HRVs. Our results showed that HRV-A and HRV-C were the predominant types of HRV infection, and HRV-C showed a high genetic variation in Chongqing, China. HRV infection was associated with asthma attacks and wheezing; furthermore, HRV infections played a minor role in causing severe pneumonia. This knowledge provides information for the prevention and control of HRV associated with ARDs.

语种: 英语
所属项目编号: 2013ZX10004202 ; 81222037
项目资助者: China Mega-Project on Infectious Disease Prevention ; National Natural Science Foundation
WOS记录号: WOS:000343590800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59780
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Anhui Med Univ, Grad Sch, Hefei, Peoples R China
3.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

Recommended Citation:
Lu, Qing-Bin,Wo, Ying,Wang, Li-Yuan,et al. Molecular Epidemiology of Human Rhinovirus in Children with Acute Respiratory Diseases in Chongqing, China[J]. SCIENTIFIC REPORTS,2014,4.
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