IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes
Chen, Jihui1,2,3; Cui, Wentong4; Zhang, Quanbin5; Jia, Yingli1,2; Sun, Yi1,2; Weng, Lin1,2; Luo, Dali4; Zhou, Hong1,2; Yang, Baoxue1,2
关键词Fucoidan diabetic nephropathy epithelialto-mesenchymal transition transforming growth factor-beta 1 extracellular matrix tubulointerstitial fibrosis
刊名AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
2015
7期:9页:1553-1563
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]GROWTH-FACTOR-BETA ; TRANSCRIPTIONAL REGULATION ; RENAL FIBROSIS ; PATHWAYS ; KIDNEY ; CANCER ; SNAIL ; RATS ; FIBROGENESIS ; HOMEOSTASIS
英文摘要

Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and may lead to end-stage renal disease (ESRD) and chronic renal failure. The aim of this study was to determine whether low-molecular-weight fucoidan (LMWF) can reduce harmful transforming growth factor-beta (TGF-beta)-mediated renal fibrosis in DN using in vitro and in vivo experimental models. The experimental results showed that LMWF significantly reversed TGF-beta 1-induced epithelial-mesenchymal transition and dose-dependently inhibited accumulation of extracellular matrix proteins, including connective tissue growth factor and fibronectin. It was found that LMWF significantly reduced blood urea nitrogen and blood creatinine in both type 1 and type 2 diabetic rat models. H&E, PAS and Masson′s trichrome staining of kidney tissue showed LMWF significantly reduced renal interstitial fibrosis. Treatment with LMWF significantly increased E-cadherin expression and reduced alpha-SMA, CTGF and fibronectin expression in both type 1 and type 2 diabetic models. LMWF also decreased the phosphorylation of Akt, ERK1/2, p38 and Smad3 in vitro and in vivo. These data suggest that LMWF may protect kidney from dysfunction and fibrogenesis by inhibiting TGF-beta pathway and have the potential benefit to slow down the progression of DN.

语种英语
WOS记录号WOS:000364771500007
项目编号81370783 ; 41376166 ; 81170632 ; 2012DFA11070 ; 2014-YY-03-04
资助机构National Natural Science Foundation of China ; 111 Project, International Science &amp ; Technology Cooperation Program of China ; Shanghai Pharmaceutical Association
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59783
专题北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Minist Educ, State Key Lab Nat & Biomimet Drugs,Key Lab Mol Ca, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Dept Pharm, Xin Hua Hosp, Shanghai 200092, Peoples R China
4.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714
Chen, Jihui,Cui, Wentong,Zhang, Quanbin,et al. Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2015,7(9):1553-1563.
APA Chen, Jihui.,Cui, Wentong.,Zhang, Quanbin.,Jia, Yingli.,Sun, Yi.,...&Yang, Baoxue.(2015).Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,7(9),1553-1563.
MLA Chen, Jihui,et al."Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 7.9(2015):1553-1563.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Low molecular weight(1811KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Jihui]的文章
[Cui, Wentong]的文章
[Zhang, Quanbin]的文章
百度学术
百度学术中相似的文章
[Chen, Jihui]的文章
[Cui, Wentong]的文章
[Zhang, Quanbin]的文章
必应学术
必应学术中相似的文章
[Chen, Jihui]的文章
[Cui, Wentong]的文章
[Zhang, Quanbin]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。