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Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis: a study of 121 patients in a single center
Chang, Dong-yuan1,2,3; Wu, Li-hua1,2,3; Liu, Gang1,2,3; Chen, Min1,2,3; Kallenberg, Cees G. M.4; Zhao, Ming-Hui1,2,3
关键词ANCA-associated glomerulonephritis end-stage renal disease renal histology
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2012-06-01
DOI10.1093/ndt/gfr643
27期:6页:2343-2349
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]SMALL-VESSEL VASCULITIS ; CHINESE PATIENTS ; PATHOLOGICAL CHARACTERISTICS ; MICROSCOPIC POLYANGIITIS ; WEGENERS-GRANULOMATOSIS ; RENAL HISTOLOGY ; AUTOANTIBODIES ; DETERMINANTS ; DISEASE ; RELAPSE
英文摘要

Background. The recently published histopathologic classification of antineutrophil cytoplasmic antibody (ANCA)associated glomerulonephritis might greatly aid in the prognostication of patients at the time of diagnosis. This study aims to re-evaluate the new classification for its prognostic capacity in an independent Chinese series.

Methods. One hundred and twenty-one consecutive patients with ANCA-associated glomerulonephritis, diagnosed in our center from 1997 to 2010, were included in this retrospective study. The renal specimens were reviewed according to the proposed histopathologic classification. The predictive value of the classification for renal outcome and renal response to treatment was analyzed.

Results. Thirty-three (27.3%), 24 (19.8%), 53 (43.8%) and 11 (9.1%) patients were classified as focal, mixed, crescentic and sclerotic ANCA-associated glomerulonephritis, respectively. The renal biopsy categories correlated with initial serum creatinine and the renal response to treatment (P < 0.001, P < 0.01, respectively). The probability of progressing to end-stage renal disease (ESRD) increased with ascending categories of focal, mixed, crescentic and sclerotic glomerulonephritis (P < 0.01). The patients with focal, mixed and crescentic ANCA-associated glomerulonephritis were all at decreased risk for developing ESRD compared with the patients with in the sclerotic category (P < 0.05).

Conclusions. The proposed classification system was re-evaluated for the first time in a relatively large and independent series of patients. This system reflects the severity of the initial renal impairment and can predict, at least to some extent, the renal response to treatment. More importantly, it can independently predict renal outcome, in particular development of ESRD.

语种英语
WOS记录号WOS:000304832100034
项目编号30725034 ; 30972733
资助机构National Science Fund for Distinguished Young Scholars ; National Natural Science Fund
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59790
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, NL-9700 AB Groningen, Netherlands
推荐引用方式
GB/T 7714
Chang, Dong-yuan,Wu, Li-hua,Liu, Gang,et al. Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis: a study of 121 patients in a single center[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2012,27(6):2343-2349.
APA Chang, Dong-yuan,Wu, Li-hua,Liu, Gang,Chen, Min,Kallenberg, Cees G. M.,&Zhao, Ming-Hui.(2012).Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis: a study of 121 patients in a single center.NEPHROLOGY DIALYSIS TRANSPLANTATION,27(6),2343-2349.
MLA Chang, Dong-yuan,et al."Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis: a study of 121 patients in a single center".NEPHROLOGY DIALYSIS TRANSPLANTATION 27.6(2012):2343-2349.
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