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学科主题: 基础医学
题名:
Promotion of myelopoiesis in myelosuppressed mice by Ganoderma lucidum polysaccharides
作者: Zhu, Xiao-Ling1; Liu, Ji-Hong2; Li, Wei-Dong1; Lin, Zhi-Bin1
关键词: Ganoderma lucidum polysaccharides ; myelosuppression ; hematopoiesis
刊名: FRONTIERS IN PHARMACOLOGY
发表日期: 2012
DOI: 10.3389/fphar.2012.00020
卷: 3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要:

Our previous studies demonstrated that Ganoderma lucidum polysaccharides (GI-PS) exhibit potent immunomodulating effects. Immunomodulation plays an important role in hematopoiesis. To investigate the possible mechanism by which GI-PS promote myelopoiesis during myelosuppression induced by cyclophosphamide, mice were injected intraperitoneally (i.p.) once daily with 2.5 mg/kg of GI-PS for 10 days and were treated i.p. once daily with cyclophosphamide (100 mg/kg) on days 2 through 4. In the present study in vivo and in vitro, we find that GI-PS selectively bind to bone marrow stromal cells, stimulate the secretion of hematopoietic growth factors, and enhance the clonogenic activities of hematopoietic and stromal cells to promote hematopoiesis in myelosuppressed mice.

语种: 英语
WOS记录号: WOS:000209177700020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59793
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth & Med Anal Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Zhu, Xiao-Ling,Liu, Ji-Hong,Li, Wei-Dong,et al. Promotion of myelopoiesis in myelosuppressed mice by Ganoderma lucidum polysaccharides[J]. FRONTIERS IN PHARMACOLOGY,2012,3.
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