IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Promotion of myelopoiesis in myelosuppressed mice by Ganoderma lucidum polysaccharides
Zhu, Xiao-Ling1; Liu, Ji-Hong2; Li, Wei-Dong1; Lin, Zhi-Bin1
关键词Ganoderma lucidum polysaccharides myelosuppression hematopoiesis
刊名FRONTIERS IN PHARMACOLOGY
2012
DOI10.3389/fphar.2012.00020
3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
英文摘要

Our previous studies demonstrated that Ganoderma lucidum polysaccharides (GI-PS) exhibit potent immunomodulating effects. Immunomodulation plays an important role in hematopoiesis. To investigate the possible mechanism by which GI-PS promote myelopoiesis during myelosuppression induced by cyclophosphamide, mice were injected intraperitoneally (i.p.) once daily with 2.5 mg/kg of GI-PS for 10 days and were treated i.p. once daily with cyclophosphamide (100 mg/kg) on days 2 through 4. In the present study in vivo and in vitro, we find that GI-PS selectively bind to bone marrow stromal cells, stimulate the secretion of hematopoietic growth factors, and enhance the clonogenic activities of hematopoietic and stromal cells to promote hematopoiesis in myelosuppressed mice.

语种英语
WOS记录号WOS:000209177700020
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59793
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth & Med Anal Ctr, Beijing 100191, Peoples R China
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Zhu, Xiao-Ling,Liu, Ji-Hong,Li, Wei-Dong,et al. Promotion of myelopoiesis in myelosuppressed mice by Ganoderma lucidum polysaccharides[J]. FRONTIERS IN PHARMACOLOGY,2012,3.
APA Zhu, Xiao-Ling,Liu, Ji-Hong,Li, Wei-Dong,&Lin, Zhi-Bin.(2012).Promotion of myelopoiesis in myelosuppressed mice by Ganoderma lucidum polysaccharides.FRONTIERS IN PHARMACOLOGY,3.
MLA Zhu, Xiao-Ling,et al."Promotion of myelopoiesis in myelosuppressed mice by Ganoderma lucidum polysaccharides".FRONTIERS IN PHARMACOLOGY 3(2012).
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