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学科主题: 临床医学
题名:
Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells
作者: Zeng, Yan1,2; Liu, Hongtao1; Kang, Kang1; Wang, Zhiwei3; Hui, Gang4; Zhang, Xiaoying1; Zhong, Jiasheng1; Peng, Wenda2; Ramchandran, Ramaswamy5; Raj, J. Usha5; Gou, Deming1,5
刊名: SCIENTIFIC REPORTS
发表日期: 2015-07-13
DOI: 10.1038/srep12098
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BONE MORPHOGENETIC PROTEIN ; ENDOTHELIAL-CELLS ; CROSS-TALK ; HYPERTENSION ; RECEPTOR ; FIBROBLASTS ; DEFICIENCY ; MECHANISMS ; MUTATIONS ; MICRORNAS
英文摘要:

There is growing evidence that microRNAs play important roles in cellular responses to hypoxia and in pulmonary hypertensive vascular remodeling, but the exact molecular mechanisms involved are not fully elucidated. In this study, we identified miR-322 as one of the microRNAs induced in lungs of chronically hypoxic mice and rats. The expression of miR-322 was also upregulated in primary cultured rat pulmonary arterial smooth muscle cells (PASMC) in response to hypoxia. We demonstrated that HIF-1 alpha, but not HIF-2 alpha, transcriptionally upregulates the expression of miR-322 in hypoxia. Furthermore, miR-322 facilitated the accumulation of HIF-1 alpha in the nucleus and promoted hypoxia-induced cell proliferation and migration. Direct targeting BMPR1a and smad5 by miR-322 was demonstrated in PASMCs suggesting that downregulation of BMP-Smad signaling pathway may be mediating the hypoxia-induced PASMC proliferation and migration. Our study implicates miR-322 in the hypoxic proliferative response of PASMCs suggesting that it may be playing a role in pulmonary vascular remodeling associated with pulmonary hypertension.

语种: 英语
所属项目编号: 81170047 ; 81370151 ; 2012CB124701 ; YFZZ20111009
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Shenzhen overseas high-level talents innovation program
WOS记录号: WOS:000357849200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59794
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shenzhen Univ, Coll Life Sci, Shenzhen Key Lab Marine Bioresourse & Ecoenvironm, Shenzhen Key Lab Microbial Genet Engn, Shenzhen 518060, Guangdong, Peoples R China
2.Shenzhen Univ, Coll Optoelect Engn, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Guangdong, Peoples R China
3.Shenzhen Sun Yat Sen Cardiovasc Hosp, Dept Cardiovasc Surg, Shenzhen 518000, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Chest Surg, Shenzhen 518000, Guangdong, Peoples R China
5.Univ Illinois, Dept Pediat, Chicago, IL 60612 USA

Recommended Citation:
Zeng, Yan,Liu, Hongtao,Kang, Kang,et al. Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells[J]. SCIENTIFIC REPORTS,2015,5.
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