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Modified donor lymphocyte infusion-associated acute graft-versus-host disease after haploidentical T-cell-replete hematopoietic stem cell transplantation: incidence and risk factors
Yan, Chen-Hua; Liu, Dai-Hong; Xu, Lan-Ping; Liu, Kai-Yan; Zhao, Ting; Wang, Yu; Chen, Huan; Chen, Yu-Hong; Han, Wei; Huang, Xiao-Jun
关键词haploidentical allogeneic hematopoietic stem cell transplantation acute graft-versus-host disease donor lymphocyte infusion graft versus leukemia
刊名CLINICAL TRANSPLANTATION
2012-11-01
DOI10.1111/j.1399-0012.2012.01618.x
26期:6页:868-876
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; CHRONIC MYELOID-LEUKEMIA ; LEUKOCYTE INFUSIONS ; WORKING PARTY ; RELAPSE ; MALIGNANCIES ; EBMT ; ADULTS ; BLOOD ; GVHD
英文摘要

We performed a study to investigate the profile of donor lymphocyte infusion (DLI)-associated acute graft-versus-host disease (GVHD) in haploidentical T-cell-replete hematopoietic stem cell transplantation (HSCT). A total of 124 patients receiving modified DLI after haploidentical T-cell-replete HSCT were enrolled. The cumulative incidence of DLI-associated acute GVHD was 53.2% for grades IIIV and 28.4% for grades IIIIV. The duration of GVHD prophylaxis after DLI was the only risk factor for DLI-associated grades IIIIV acute GVHD (p < 0.05). The cumulative incidence of grades IIIIV acute GVHD in patients with prophylaxis more than six, four to six, two to four, and <2 wk were 9.3%, 14.4%, 31.6%, and 49.5%, respectively (p = 0.018). Furthermore, DLI-associated grades IIIIV acute GVHD was the only risk factor for overall survival (p = 0.038, OR = 2.869) and transplant-related mortality (p = 0.018, OR = 3.296) but not a risk factor for relapse after DLI (p = 0.840). This study confirms for the first time that the duration of GVHD prophylaxis after DLI is the only risk factor for the development of grades IIIIV acute GVHD. Donor lymphocyte infusion with prophylaxis more than six wk was associated with a lower incidence of grades IIIIV acute GVHD.

语种英语
WOS记录号WOS:000312129100019
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被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59795
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
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Yan, Chen-Hua,Liu, Dai-Hong,Xu, Lan-Ping,et al. Modified donor lymphocyte infusion-associated acute graft-versus-host disease after haploidentical T-cell-replete hematopoietic stem cell transplantation: incidence and risk factors[J]. CLINICAL TRANSPLANTATION,2012,26(6):868-876.
APA Yan, Chen-Hua.,Liu, Dai-Hong.,Xu, Lan-Ping.,Liu, Kai-Yan.,Zhao, Ting.,...&Huang, Xiao-Jun.(2012).Modified donor lymphocyte infusion-associated acute graft-versus-host disease after haploidentical T-cell-replete hematopoietic stem cell transplantation: incidence and risk factors.CLINICAL TRANSPLANTATION,26(6),868-876.
MLA Yan, Chen-Hua,et al."Modified donor lymphocyte infusion-associated acute graft-versus-host disease after haploidentical T-cell-replete hematopoietic stem cell transplantation: incidence and risk factors".CLINICAL TRANSPLANTATION 26.6(2012):868-876.
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