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学科主题: 医学信息学
题名:
Anti-Hsp20 antibody concentrations inversely correlated with tumor progression in ovarian cancer
作者: Zhu, Yanhui1; Tian, Qingchao2; Qiao, Naian3; Cheng, Yin4; Li, Haiying5
关键词: Heat shock protein ; Hsp20 ; Ovarian cancer
刊名: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
发表日期: 2015
卷: 36, 期:4, 页:394-396
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: ISCHEMIA/REPERFUSION-INJURY ; HEAT-SHOCK-PROTEIN-20 ; HSP27 ; CELLS
英文摘要:

Purpose: To investigate the serum concentrations of anti-heat shock protein 20 (anti-Hsp20) antibodies in women with ovarian cancer at different clinical stages, and the relationship between these concentrations and tumor progression. Materials and Methods: Blood samples were obtained from 72 patients undergoing surgery for ovarian cancer, 21 women with ovarian carcinoid, and 42 healthy women. Anti-Hsp20 antibody concentrations were determined by enzyme-linked immunosorbent assay. Results: Mean anti-Hsp20 antibody concentrations were significantly lower in patients with ovarian cancer than in the control group. The anti-Hsp20 antibody concentrations were negatively correlated with ovarian cancer malignancy. Conclusions: The present findings suggest that anti-Hsp20 antibodies may play a protective role against ovarian cancer progression, and that anti-Hsp20 antibodies may be a new index for the early diagnosis and treatment of ovarian cancer.

语种: 英语
WOS记录号: WOS:000359035700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59798
Appears in Collections:北京大学医学信息学中心_期刊论文

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作者单位: 1.Peking Univ, Med Informat Ctr, Beijing 100191, Peoples R China
2.Jinan Third Peoples Hosp, Dept Obstet & Gynecol, Jinan, Peoples R China
3.Jinan Third Peoples Hosp, Dept Sci & Educ, Jinan, Peoples R China
4.Shandong Univ, Qilu Hosp, Dept Radiotherapy, Jinan 250100, Peoples R China
5.Shandong Univ, Qilu Hosp, Div Ultrasonog, Jinan 250100, Peoples R China

Recommended Citation:
Zhu, Yanhui,Tian, Qingchao,Qiao, Naian,et al. Anti-Hsp20 antibody concentrations inversely correlated with tumor progression in ovarian cancer[J]. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY,2015,36(4):394-396.
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