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学科主题: 药学
题名:
Determination of Anti-Tumor Agent TM208, 4-Methyl-piperazine-1-carbodithioc Acid 3-Cyano-3,3-diphenylpropyl Ester Hydrochloride, in Rats by LC
作者: Kong, Detao1; Wang, Siting1; Ling, Xiaomei1; Li, Runtao2; Cui, Jingrong2
关键词: Liquid chromatography ; Dithiocarbamate ; Rat organs and plasma samples ; Distribution
刊名: CHROMATOGRAPHIA
发表日期: 2009-12-01
DOI: 10.1365/s10337-009-1402-7
卷: 70, 期:11-12, 页:1721-1725
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: PARKINSONS-DISEASE PHENOTYPE ; ETHYLENE-BIS-DITHIOCARBAMATE ; TANDEM MASS-SPECTROMETRY ; COMBINED PARAQUAT ; MANEB ; DIETHYLDITHIOCARBAMATE ; INHIBITION ; METABOLISM ; PESTICIDES ; EXPOSURE
英文摘要:

A new, specific and sensitive high performance liquid chromatography analytical procedure was developed and validated for the determination of TM208 in rat primary solid organs/tissues and plasma. TM208 was extracted from the appropriate matrix using methanol followed by centrifugation at 11,255xg for 20 min and injection of a 30 mu L aliquot. Separation was carried out under gradient conditions using an ODS C18 column equipped with a guard column. The mobile phase consisted of methanol and water and retention times of TM208 and plunarizine (IS) were 17.658 and 26.175 min, respectively. The analytical procedure provided acceptable precision, accuracy, recoveries and linearity. Stability studies showed that TM208 was stable in organs/tissues homogenates for three freeze-thaw cycles, at room temperature for at least 24 h 3 weeks at -20 A degrees C. The validated method was successfully applied to the determination of TM208 in SD rats following oral administration at a dose of 250 mg kg(-1).

语种: 英语
所属项目编号: 2004AA2Z3783 ; 20172006
项目资助者: National Basic Research Program of China (863 Program) ; National Science Foundation of China (NSFC)
WOS记录号: WOS:000272173800030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59801
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut Anal, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Kong, Detao,Wang, Siting,Ling, Xiaomei,et al. Determination of Anti-Tumor Agent TM208, 4-Methyl-piperazine-1-carbodithioc Acid 3-Cyano-3,3-diphenylpropyl Ester Hydrochloride, in Rats by LC[J]. CHROMATOGRAPHIA,2009,70(11-12):1721-1725.
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