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Determination of Anti-Tumor Agent TM208, 4-Methyl-piperazine-1-carbodithioc Acid 3-Cyano-3,3-diphenylpropyl Ester Hydrochloride, in Rats by LC
Kong, Detao1; Wang, Siting1; Ling, Xiaomei1; Li, Runtao2; Cui, Jingrong2
关键词Liquid chromatography Dithiocarbamate Rat organs and plasma samples Distribution
刊名CHROMATOGRAPHIA
2009-12-01
DOI10.1365/s10337-009-1402-7
70期:11-12页:1721-1725
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PARKINSONS-DISEASE PHENOTYPE ; ETHYLENE-BIS-DITHIOCARBAMATE ; TANDEM MASS-SPECTROMETRY ; COMBINED PARAQUAT ; MANEB ; DIETHYLDITHIOCARBAMATE ; INHIBITION ; METABOLISM ; PESTICIDES ; EXPOSURE
英文摘要

A new, specific and sensitive high performance liquid chromatography analytical procedure was developed and validated for the determination of TM208 in rat primary solid organs/tissues and plasma. TM208 was extracted from the appropriate matrix using methanol followed by centrifugation at 11,255xg for 20 min and injection of a 30 mu L aliquot. Separation was carried out under gradient conditions using an ODS C18 column equipped with a guard column. The mobile phase consisted of methanol and water and retention times of TM208 and plunarizine (IS) were 17.658 and 26.175 min, respectively. The analytical procedure provided acceptable precision, accuracy, recoveries and linearity. Stability studies showed that TM208 was stable in organs/tissues homogenates for three freeze-thaw cycles, at room temperature for at least 24 h 3 weeks at -20 A degrees C. The validated method was successfully applied to the determination of TM208 in SD rats following oral administration at a dose of 250 mg kg(-1).

语种英语
WOS记录号WOS:000272173800030
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59801
专题北京大学药学院_化学生物学系
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut Anal, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Kong, Detao,Wang, Siting,Ling, Xiaomei,et al. Determination of Anti-Tumor Agent TM208, 4-Methyl-piperazine-1-carbodithioc Acid 3-Cyano-3,3-diphenylpropyl Ester Hydrochloride, in Rats by LC[J]. CHROMATOGRAPHIA,2009,70(11-12):1721-1725.
APA Kong, Detao,Wang, Siting,Ling, Xiaomei,Li, Runtao,&Cui, Jingrong.(2009).Determination of Anti-Tumor Agent TM208, 4-Methyl-piperazine-1-carbodithioc Acid 3-Cyano-3,3-diphenylpropyl Ester Hydrochloride, in Rats by LC.CHROMATOGRAPHIA,70(11-12),1721-1725.
MLA Kong, Detao,et al."Determination of Anti-Tumor Agent TM208, 4-Methyl-piperazine-1-carbodithioc Acid 3-Cyano-3,3-diphenylpropyl Ester Hydrochloride, in Rats by LC".CHROMATOGRAPHIA 70.11-12(2009):1721-1725.
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