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学科主题: 临床医学
题名:
COM-1/p8 Acts as a Tumour Growth Enhancer in Colorectal Cancer Cell Lines
作者: Li, Xin1,2; Martin, Tracey A.1; Jiang, Wen G.1
关键词: COM-1 ; p8 ; NUPR1 ; colorectal cancer ; cell growth ; cell migration ; apoptosis ; PPAR gamma agonist
刊名: ANTICANCER RESEARCH
发表日期: 2012-04-01
卷: 32, 期:4, 页:1229-1237
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ACTIVATED RECEPTOR-GAMMA ; PROSTATE-CANCER ; PPAR-GAMMA ; PANCREATIC-CANCER ; EXPRESSION ; P8 ; APOPTOSIS ; PROTEIN ; DIFFERENTIATION ; DEFICIENCY
英文摘要:

Background: Candidate of metastasis-1 (COM-1) is a molecule which is stress-induced and cell growth-related. The current study investigated the impact of COM-1 and role of Peroxisome Proliferating Activator Receptor-gamma (PPAR gamma) agonists on COM-1 knock down in colorectal cancer cells. Materials and Methods: Expression of COM-1 was knocked out in the colorectal cancer cell lines RKO and CaCO2 by transfection with ribozyme transgenes which specifically targeted COM-1. Cell growth, cell migration and apoptosis were measured in wild-type, control and COM-1 knock down cells. The impact or treatment with the PPAR gamma agonists on the function of COM-1 knock down cells was monitored. Results: COM-1 knockdown cells grew slower than wild-type and control cells. When treated with the PPAR gamma agonist ciglitazone and bisphenol A diglycidyl ether (BADGE) at several different concentrations, all types of cells grew slower to some extent. Cells with COM-1 knock-down had the same mobility as wild-type and control cells. More apoptotic and dead cells were detected when cells were treated with ciglitazone at 3 mu M, especially of COM-1 knock down cells. Conclusion: COM-1 is an anti-apoptotic gene and a cell growth promoter. Furthermore, the PPAR gamma agonist could increase the inhibitory effect seen in COM-1 knock-down cell growth and to promote apoptosis. In regards to metastasis, COM-1 appears to play no role in cell motility.

语种: 英语
项目资助者: Cardiff University ; Albert Hung Foundation ; Cancer Research Wales
WOS记录号: WOS:000302492600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59809
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Cardiff Univ, Sch Med, Inst Canc & Genet, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales
2.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100871, Peoples R China

Recommended Citation:
Li, Xin,Martin, Tracey A.,Jiang, Wen G.. COM-1/p8 Acts as a Tumour Growth Enhancer in Colorectal Cancer Cell Lines[J]. ANTICANCER RESEARCH,2012,32(4):1229-1237.
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