北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 老年病内科  > 期刊论文
学科主题: 临床医学
题名:
Diallyl disulfide inhibits proliferation and transdifferentiation of lung fibroblasts through induction of cyclooxygenase and synthesis of prostaglandin E-2
作者: Wang, Yanhua1; Cao, Rong2; Wei, Bo1; Chai, Xiaoyu1; Sun, Dan1; Guan, Y.2; Liu, Xin-min1
关键词: Diallyl disulfide ; Cyclooxygenase ; PGE2 ; Fibrosis ; Histone acetylation
刊名: MOLECULAR AND CELLULAR BIOCHEMISTRY
发表日期: 2014-08-01
DOI: 10.1007/s11010-014-2048-9
卷: 393, 期:1-2, 页:77-87
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: IDIOPATHIC PULMONARY-FIBROSIS ; INCREASES HISTONE ACETYLATION ; NF-KAPPA-B ; NITRIC-OXIDE ; MYOFIBROBLAST DIFFERENTIATION ; STIMULATED MACROPHAGES ; GARLIC OIL ; CELL-LINES ; EXPRESSION ; MECHANISMS
英文摘要:

Platelet-derived growth factor-BB (PDGF-BB) and transforming growth factor-beta 1 (TGF-beta 1) are critically involved in idiopathic pulmonary fibrosis by inducing the proliferation and transdifferentiation of lung fibroblasts. In the present study, we examined the impact of diallyl disulfide (DADS), a garlic-derived compound, on such pathological conditions. DADS showed profound inhibitory effects on the PDGF-BB-induced proliferation of human and mouse lung fibroblasts. DADS also abrogated the TGF-beta 1-induced expression of alpha-smooth muscle actin, type I collagen and fibronectin. Following treatment with DADS, the expression of cyclooxygenase-2 (COX-2) and the synthesis of prostaglandin E-2 (PGE(2)) were found to be markedly enhanced, which in turn led to elevated cAMP levels in lung fibroblasts. Notably, the effect of DADS was largely abolished in the presence of either COX inhibitor indomethacin or siRNA-targeting COX-2, or in the absence of the PGE(2) receptor EP2, supporting an essential role for the COX-2-PGE(2)-cAMP autocrine loop. Furthermore, we demonstrated that the upregulated expression of COX-2 was a result of increased level of histone 3 acetylation at COX-2 locus in DADS-treated cells. Together, these results suggest that DADS, by inducing COX-2 expression, may have therapeutic potential in treating lung fibrosis.

语种: 英语
所属项目编号: 81270114
项目资助者: National Natural Sciences Foundation of China
WOS记录号: WOS:000338348700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59813
Appears in Collections:北京大学第一临床医学院_老年病内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Geriatr, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Yanhua,Cao, Rong,Wei, Bo,et al. Diallyl disulfide inhibits proliferation and transdifferentiation of lung fibroblasts through induction of cyclooxygenase and synthesis of prostaglandin E-2[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2014,393(1-2):77-87.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Yanhua]'s Articles
[Cao, Rong]'s Articles
[Wei, Bo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Yanhua]‘s Articles
[Cao, Rong]‘s Articles
[Wei, Bo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace