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学科主题基础医学
LAPTM4B Allele*2 Is a Marker of Poor Prognosis Following Hepatic Tumor Resection for Hepatocellular Carcinoma
Yang, Hua1; Zhai, Guojun2; Ji, Xiaoxu3; Xiong, Fuxia4; Su, Jing5; McNutt, Michael A.5
刊名PLOS ONE
2012-04-03
DOI10.1371/journal.pone.0034984
7期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GALLBLADDER CARCINOMA ; OVARIAN-CARCINOMA ; GENE POLYMORPHISM ; OVEREXPRESSION ; CANCER ; CELLS ; SUSCEPTIBILITY ; METASTASIS ; RESISTANCE ; EXPRESSION
英文摘要

Background: Lysosomal protein transmembrane 4 beta (LAPTM4B) is a gene related to hepatocellular carcinoma that has two alleles designated LAPTM4B*1 and LAPTM4B*2. This study aimed to investigate the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who have undergone resection for hepatocellular carcinoma (HCC).

Methodology/Principal Findings: The LAPTM4B genotype was analyzed by PCR in 68 patients who had undergone curative hepatic resection for hepatocellular carcinoma. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P<0.001). Multivariate analysis showed that LAPTM4B genotype is an independent prognostic factor for OS and DFS (both P<0.001).

Conclusions/Significance: Allele *2 of LAPTM4B is a risk factor associated with poor prognosis in patients with resected HCC. LAPTM4B status may be useful preoperatively as an adjunct in evaluation of the operability of HCC.

语种英语
WOS记录号WOS:000304805900063
项目编号31000622 ; 20100001120043
资助机构National Nature Science Fund ; Specialized Research Fund for the Doctoral Program of Higher Education of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59814
专题北京大学基础医学院_细胞生物学系
北京大学基础医学院
作者单位1.Loma Linda Univ, Dept Pharmacol, Loma Linda, CA 92350 USA
2.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Dept Intervent Radiol & Vasc Surg, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100871, Peoples R China
5.Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100871, Peoples R China
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GB/T 7714
Yang, Hua,Zhai, Guojun,Ji, Xiaoxu,et al. LAPTM4B Allele*2 Is a Marker of Poor Prognosis Following Hepatic Tumor Resection for Hepatocellular Carcinoma[J]. PLOS ONE,2012,7(4).
APA Yang, Hua,Zhai, Guojun,Ji, Xiaoxu,Xiong, Fuxia,Su, Jing,&McNutt, Michael A..(2012).LAPTM4B Allele*2 Is a Marker of Poor Prognosis Following Hepatic Tumor Resection for Hepatocellular Carcinoma.PLOS ONE,7(4).
MLA Yang, Hua,et al."LAPTM4B Allele*2 Is a Marker of Poor Prognosis Following Hepatic Tumor Resection for Hepatocellular Carcinoma".PLOS ONE 7.4(2012).
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