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学科主题: 基础医学
题名:
LAPTM4B Allele*2 Is a Marker of Poor Prognosis Following Hepatic Tumor Resection for Hepatocellular Carcinoma
作者: Yang, Hua1; Zhai, Guojun2; Ji, Xiaoxu3; Xiong, Fuxia4; Su, Jing5; McNutt, Michael A.5
刊名: PLOS ONE
发表日期: 2012-04-03
DOI: 10.1371/journal.pone.0034984
卷: 7, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GALLBLADDER CARCINOMA ; OVARIAN-CARCINOMA ; GENE POLYMORPHISM ; OVEREXPRESSION ; CANCER ; CELLS ; SUSCEPTIBILITY ; METASTASIS ; RESISTANCE ; EXPRESSION
英文摘要:

Background: Lysosomal protein transmembrane 4 beta (LAPTM4B) is a gene related to hepatocellular carcinoma that has two alleles designated LAPTM4B*1 and LAPTM4B*2. This study aimed to investigate the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who have undergone resection for hepatocellular carcinoma (HCC).

Methodology/Principal Findings: The LAPTM4B genotype was analyzed by PCR in 68 patients who had undergone curative hepatic resection for hepatocellular carcinoma. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P<0.001). Multivariate analysis showed that LAPTM4B genotype is an independent prognostic factor for OS and DFS (both P<0.001).

Conclusions/Significance: Allele *2 of LAPTM4B is a risk factor associated with poor prognosis in patients with resected HCC. LAPTM4B status may be useful preoperatively as an adjunct in evaluation of the operability of HCC.

语种: 英语
所属项目编号: 31000622 ; 20100001120043
项目资助者: National Nature Science Fund ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000304805900063
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59814
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Loma Linda Univ, Dept Pharmacol, Loma Linda, CA 92350 USA
2.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Dept Intervent Radiol & Vasc Surg, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100871, Peoples R China
5.Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Hua,Zhai, Guojun,Ji, Xiaoxu,et al. LAPTM4B Allele*2 Is a Marker of Poor Prognosis Following Hepatic Tumor Resection for Hepatocellular Carcinoma[J]. PLOS ONE,2012,7(4).
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