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学科主题: 药学
题名:
RNA-seq identified a super-long intergenic transcript functioning in adipogenesis
作者: Yi, Fan1,2; Yang, Feng1,2; Liu, Xiaoqiao1,2; Chen, Hongbo1,2; Ji, Ting3; Jiang, Lixiang3; Wang, Xiaoxia1,2; Yang, Zhangping4; Zhang, Li-He1,2; Ding, Xianfeng3; Liang, Zicai1,2; Du, Quan1,2
关键词: large intergenic non-coding RNA ; polyA-minus RNA ; adipogenesis ; obesity ; high-throughput sequencing
刊名: RNA BIOLOGY
发表日期: 2013-06-01
DOI: 10.4161/rna.24644
卷: 10, 期:6, 页:991-1002
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: ACTIVATED RECEPTOR-GAMMA ; BINDING PROTEIN-ALPHA ; PEROXISOME PROLIFERATOR ; NONCODING RNA ; PPAR-GAMMA ; INSULIN-RESISTANCE ; LINKING OBESITY ; C/EBP-ALPHA ; EXPRESSION ; GENE
英文摘要:

RNA transcripts are generally classified into polyA-plus and polyA-minus subgroups due to the presence or absence of a polyA tail at the 3 end. Even though a number of physiologically and pathologically important polyA-minus RNAs have been recently identified, a systematic analysis of the expression and function of these transcripts in adipogenesis is still elusive. To study the potential function of the polyA-minus RNAs in adipogenesis, a dynamic expressional profiling was performed in the induced differentiation of 3T3-L1 cells. In addition to identifying thousands of novel intergenic transcripts, differentiation-synchronized expression was characterized for many of them. Among these, several large intergenic transcripts were found to be upregulated by more than 19-fold during differentiation. Further study demonstrated a fat tissue-specific expression pattern for these regions and identified an adipogenesis-associated long non-coding RNA. Collectively, these lines of evidence contribute to the characterization of a super-long intergenic transcript functioning in adipogenesis.

语种: 英语
所属项目编号: 2011CBA01102 ; 5132015 ; 2012AA022501 ; Y2100681 ; 2011B090400478 ; 20110733Q21
项目资助者: National Basic Research Program of China ; Beijing Natural Science Foundation ; National High-tech R&amp ; D Program of China ; Zhejiang Provincial Natural Science Foundation of China ; Guangdong Science and Technology Department ; Hangzhou Science and Technology Bureau
WOS记录号: WOS:000327574000011
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59818
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Inst Mol Med, Lab Nucle Acid Technol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Inst Mol Med, Lab State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
3.Zhejiang Sci Tech Univ, Sch Life Sci, Hangzhou, Zhejiang, Peoples R China
4.Hangzhou Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China

Recommended Citation:
Yi, Fan,Yang, Feng,Liu, Xiaoqiao,et al. RNA-seq identified a super-long intergenic transcript functioning in adipogenesis[J]. RNA BIOLOGY,2013,10(6):991-1002.
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