北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
RNA-seq identified a super-long intergenic transcript functioning in adipogenesis
作者: Yi, Fan1,2; Yang, Feng1,2; Liu, Xiaoqiao1,2; Chen, Hongbo1,2; Ji, Ting3; Jiang, Lixiang3; Wang, Xiaoxia1,2; Yang, Zhangping4; Zhang, Li-He1,2; Ding, Xianfeng3; Liang, Zicai1,2; Du, Quan1,2
关键词: large intergenic non-coding RNA ; polyA-minus RNA ; adipogenesis ; obesity ; high-throughput sequencing
刊名: RNA BIOLOGY
发表日期: 2013-06-01
DOI: 10.4161/rna.24644
卷: 10, 期:6, 页:991-1002
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: ACTIVATED RECEPTOR-GAMMA ; BINDING PROTEIN-ALPHA ; PEROXISOME PROLIFERATOR ; NONCODING RNA ; PPAR-GAMMA ; INSULIN-RESISTANCE ; LINKING OBESITY ; C/EBP-ALPHA ; EXPRESSION ; GENE
英文摘要:

RNA transcripts are generally classified into polyA-plus and polyA-minus subgroups due to the presence or absence of a polyA tail at the 3 end. Even though a number of physiologically and pathologically important polyA-minus RNAs have been recently identified, a systematic analysis of the expression and function of these transcripts in adipogenesis is still elusive. To study the potential function of the polyA-minus RNAs in adipogenesis, a dynamic expressional profiling was performed in the induced differentiation of 3T3-L1 cells. In addition to identifying thousands of novel intergenic transcripts, differentiation-synchronized expression was characterized for many of them. Among these, several large intergenic transcripts were found to be upregulated by more than 19-fold during differentiation. Further study demonstrated a fat tissue-specific expression pattern for these regions and identified an adipogenesis-associated long non-coding RNA. Collectively, these lines of evidence contribute to the characterization of a super-long intergenic transcript functioning in adipogenesis.

语种: 英语
所属项目编号: 2011CBA01102 ; 5132015 ; 2012AA022501 ; Y2100681 ; 2011B090400478 ; 20110733Q21
项目资助者: National Basic Research Program of China ; Beijing Natural Science Foundation ; National High-tech R&amp ; D Program of China ; Zhejiang Provincial Natural Science Foundation of China ; Guangdong Science and Technology Department ; Hangzhou Science and Technology Bureau
WOS记录号: WOS:000327574000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59818
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Inst Mol Med, Lab Nucle Acid Technol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Inst Mol Med, Lab State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
3.Zhejiang Sci Tech Univ, Sch Life Sci, Hangzhou, Zhejiang, Peoples R China
4.Hangzhou Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China

Recommended Citation:
Yi, Fan,Yang, Feng,Liu, Xiaoqiao,et al. RNA-seq identified a super-long intergenic transcript functioning in adipogenesis[J]. RNA BIOLOGY,2013,10(6):991-1002.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yi, Fan]'s Articles
[Yang, Feng]'s Articles
[Liu, Xiaoqiao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yi, Fan]‘s Articles
[Yang, Feng]‘s Articles
[Liu, Xiaoqiao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace