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学科主题药学
Kaempferol Derivatives Prevent Oxidative Stress-Induced Cell Death in a DJ-1-Dependent Manner
Qu, Wei1,3; Fan, Li2; Kim, Yun-chul3; Ishikawa, Shizuma4; Iguchi-Ariga, Sanae M. M.4; Pu, Xiao-Ping1; Ariga, Hiroyoshi3
关键词DJ-1 traditional Chinese medicine cell death oxidative stress Parkinson&prime s disease
刊名JOURNAL OF PHARMACOLOGICAL SCIENCES
2009-06-01
DOI10.1254/jphs.09045FP
110期:2页:191-200
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PARKINSONS-DISEASE ; HYDROGEN-PEROXIDE ; ISCHEMIA-REPERFUSION ; ANTIOXIDATIVE STRESS ; ANDROGEN RECEPTOR ; ALPHA-SYNUCLEIN ; DJ-1 PROTECTS ; INJURY ; PARK7 ; RATS
英文摘要

DJ-1, a causative gene product of a familial form of Parkinson′s disease (PD), PARK7, plays a role in anti-oxidative stress, and loss of its function is thought to result in the onset of PD. Superfluous oxidation of cysteine at amino acid 106 (C106) of DJ-I renders DJ-1 inactive, and such oxidized DJ-I was observed in patients with the sporadic form of PD. In this study, we examined the relationship between DJ-1 and Compounds extracted from traditional Chinese medicines possessing anti-oxidant activity. Of the 12 compounds tested, 5 were found to specifically bind to the C106 region by using a quartz crystal microbalance. Although 4 compounds prevented rat PC12 and primary neuronal cells from undergoing H(2)O(2)-induced cell death, the protective activity of 2 compounds, kaempferol 3-O-beta-rutinoside and 6-hydroxy-kaempferol 3,6-di-O-beta-D-glucoside, was diminished in cells transfected with siRNA targeting DJ-1, indicating DJ-1-dependent reaction of these compounds. Furthermore, these compounds reduced the level of reactive oxygen species and restored tyrosine hydroxylase activity that had been induced and compromised, respectively, by treatment of cells with H(2)O(2). The results suggest that these compounds are useful lead compounds for PD therapy.

语种英语
WOS记录号WOS:000267457000007
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59826
Collection北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Hokkaido Univ, Mol Biol Lab, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
4.Hokkaido Univ, Lab Environm Mol Biosci, Grad Sch Agr, Sapporo, Hokkaido 0608589, Japan
Recommended Citation
GB/T 7714
Qu, Wei,Fan, Li,Kim, Yun-chul,et al. Kaempferol Derivatives Prevent Oxidative Stress-Induced Cell Death in a DJ-1-Dependent Manner[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2009,110(2):191-200.
APA Qu, Wei.,Fan, Li.,Kim, Yun-chul.,Ishikawa, Shizuma.,Iguchi-Ariga, Sanae M. M..,...&Ariga, Hiroyoshi.(2009).Kaempferol Derivatives Prevent Oxidative Stress-Induced Cell Death in a DJ-1-Dependent Manner.JOURNAL OF PHARMACOLOGICAL SCIENCES,110(2),191-200.
MLA Qu, Wei,et al."Kaempferol Derivatives Prevent Oxidative Stress-Induced Cell Death in a DJ-1-Dependent Manner".JOURNAL OF PHARMACOLOGICAL SCIENCES 110.2(2009):191-200.
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