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学科主题: 药学
题名:
Kaempferol Derivatives Prevent Oxidative Stress-Induced Cell Death in a DJ-1-Dependent Manner
作者: Qu, Wei1,3; Fan, Li2; Kim, Yun-chul3; Ishikawa, Shizuma4; Iguchi-Ariga, Sanae M. M.4; Pu, Xiao-Ping1; Ariga, Hiroyoshi3
关键词: DJ-1 ; traditional Chinese medicine ; cell death ; oxidative stress ; Parkinson&prime ; s disease
刊名: JOURNAL OF PHARMACOLOGICAL SCIENCES
发表日期: 2009-06-01
DOI: 10.1254/jphs.09045FP
卷: 110, 期:2, 页:191-200
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PARKINSONS-DISEASE ; HYDROGEN-PEROXIDE ; ISCHEMIA-REPERFUSION ; ANTIOXIDATIVE STRESS ; ANDROGEN RECEPTOR ; ALPHA-SYNUCLEIN ; DJ-1 PROTECTS ; INJURY ; PARK7 ; RATS
英文摘要:

DJ-1, a causative gene product of a familial form of Parkinson′s disease (PD), PARK7, plays a role in anti-oxidative stress, and loss of its function is thought to result in the onset of PD. Superfluous oxidation of cysteine at amino acid 106 (C106) of DJ-I renders DJ-1 inactive, and such oxidized DJ-I was observed in patients with the sporadic form of PD. In this study, we examined the relationship between DJ-1 and Compounds extracted from traditional Chinese medicines possessing anti-oxidant activity. Of the 12 compounds tested, 5 were found to specifically bind to the C106 region by using a quartz crystal microbalance. Although 4 compounds prevented rat PC12 and primary neuronal cells from undergoing H(2)O(2)-induced cell death, the protective activity of 2 compounds, kaempferol 3-O-beta-rutinoside and 6-hydroxy-kaempferol 3,6-di-O-beta-D-glucoside, was diminished in cells transfected with siRNA targeting DJ-1, indicating DJ-1-dependent reaction of these compounds. Furthermore, these compounds reduced the level of reactive oxygen species and restored tyrosine hydroxylase activity that had been induced and compromised, respectively, by treatment of cells with H(2)O(2). The results suggest that these compounds are useful lead compounds for PD therapy.

语种: 英语
所属项目编号: 2004CB518902
项目资助者: Ministry or Education, Science, Culture, and Sports of Japan ; Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO) in Japan ; National Program for Key Basic Research Projects of China ; National Basic Research Program of China ; China Scholarship Council (CSC)
WOS记录号: WOS:000267457000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59826
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Hokkaido Univ, Mol Biol Lab, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
4.Hokkaido Univ, Lab Environm Mol Biosci, Grad Sch Agr, Sapporo, Hokkaido 0608589, Japan

Recommended Citation:
Qu, Wei,Fan, Li,Kim, Yun-chul,et al. Kaempferol Derivatives Prevent Oxidative Stress-Induced Cell Death in a DJ-1-Dependent Manner[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2009,110(2):191-200.
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