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学科主题: 药学
题名:
Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting
作者: Duan, Cunxian1; Zhang, Dianrui1; Wang, Feihu1; Zheng, Dandan1; Jia, Lejiao1; Feng, Feifei1; Liu, Yue1; Wang, Yancai1; Tian, Keli2; Wang, Fengshan3; Zhang, Qiang4
关键词: Nanogels ; Chitosan ; N-isopropylacrylamide ; Tumor extracellular pH ; Oridonin
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2011-05-16
DOI: 10.1016/j.ijpharm.2011.02.050
卷: 409, 期:1-2, 页:252-259
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DRUG-DELIVERY ; IN-VITRO ; N-ISOPROPYLACRYLAMIDE ; PH ; NANOPARTICLES ; MICELLES ; CHITOSAN ; HYDROGELS ; RELEASE ; VIVO
英文摘要:

The principle objective of this research was to develop and characterize pH-responsive and biocompatible nanogels as a tumor-targeting drug delivery system. The nanogels were self-assembled from chitosan-based copolymers, chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAm). The copolymers were synthesized via free radical copolymerization and characterized for their chemical structure by FT-IR and (1)H NMR. These copolymers could be efficiently loaded with oridonin (ORI) and the characteristics of ORI-loaded nanogels were evaluated. Drug release researches indicated that the ORI-loaded nanogels displayed pH-dependent release behaviors. Based on MTT assay and cellular morphological analysis, the anti-tumor activity of ORI-loaded nanogels was higher at pH 6.5 than at pH 7.4. In conclusion, the obtained nanogels appeared to be of great promise in tumor extracellular pH targeting for ORI. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81073054 ; 2009CB930300
项目资助者: National Nature Science Foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000290135800032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59828
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Shandong Univ, Sch Med, Inst Biochem & Mol Biol, Jinan 250012, Peoples R China
3.Shandong Univ, Sch Pharmaceut Sci, Natl Glycoengn Res Ctr, Jinan 250012, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Duan, Cunxian,Zhang, Dianrui,Wang, Feihu,et al. Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2011,409(1-2):252-259.
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