北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Clinical trial of arotinolol in the treatment of hypertension: Dippers vs. non-dippers
作者: Wu, HY; Zhang, YQ; Huang, HF; Zhang, YH; Liu, GZ; Sun, NL; Yu, ZQ; Zhou, YR
关键词: ambulatory blood pressure monitoring ; hypertension ; arotinolol
刊名: HYPERTENSION RESEARCH
发表日期: 2001-09-01
卷: 24, 期:5, 页:605-610
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: BLOOD-PRESSURE ; REPRODUCIBILITY ; COMBINATION ; NIFEDIPINE
英文摘要:

To compare the effects of an a, P blocker, arotinolol, in the treatment of essential hypertension between patients with a dipper and those with a non-dipper profile by means of 24-h ambulatory blood pressure monitoring (ABPM), a multicenter single blind parallel trial was carried out in five clinical centers. After a one-week single blind placebo run-in period, the patients underwent ABPM if their clinic diastolic blood pressure (DBP) ranged from 90-109 mmHg and their clinic systolic blood pressure (SBP) was < 180 mmHg. They were divided into two groups according to the absence (non-dipper group, 24 cases) or presence (dipper group, 23 cases) of nocturnal BP reduction greater than or equal to 10% of daytime BP. ABPM was measured again at the end of the active treatment phase. All patients were given Arotinolol 10-20 mg twice daily for 4 weeks. Twenty four-hour systolic and diastolic average BPs (MSBP, MDBP), 24-h systolic and diastolic blood pressure load (LS BID, LDBP), daytime systolic and diastolic average BPs (dMSBP, dMDBP), daytime systolic and diastolic blood pressure load (dLSBP, dLDBP), nighttime systolic and diastolic average Bps (nMSBP, nMDBP) and nighttime systolic and diastolic blood pressure load (nLSBP, nLDBP) were calculated. Arotinolol was effective in 78.2% of dippers and 54.2% of non-dippers, but the difference in effectiveness between these groups was not statistically significant. After treatment, SBP and DBP-including 24-h, daytime and nighttime systolic and diastolic BPs- were significantly reduced in both groups. During the daytime period, the systolic and diastolic blood pressures were significantly reduced in both dippers and non-dippers, while nighttime systolic and diastolic blood pressures were significantly reduced only in the non-dipper group. No significant changes were found in the dipper group over this period. In conclusion, Arotinolol, which can be dosed twice daily, is an effective antihypertensive agent which effectively lowers blood pressure during the day while reducing nighttime blood pressure more in non-dippers than in dippers, without excessive lowering blood pressure in the latter.

语种: 英语
WOS记录号: WOS:000171603100021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59829
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Anzhen Hosp, Beijing, Peoples R China
3.Beijing Univ, Hosp 1, Beijing 100871, Peoples R China
4.Fu Wai Hosp, Chinese Acad Med Sci, Beijing 100037, Peoples R China
5.PUMC, Beijing 100037, Peoples R China

Recommended Citation:
Wu, HY,Zhang, YQ,Huang, HF,et al. Clinical trial of arotinolol in the treatment of hypertension: Dippers vs. non-dippers[J]. HYPERTENSION RESEARCH,2001,24(5):605-610.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, HY]'s Articles
[Zhang, YQ]'s Articles
[Huang, HF]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, HY]‘s Articles
[Zhang, YQ]‘s Articles
[Huang, HF]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace