IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Clinical trial of arotinolol in the treatment of hypertension: Dippers vs. non-dippers
Wu, HY; Zhang, YQ; Huang, HF; Zhang, YH; Liu, GZ; Sun, NL; Yu, ZQ; Zhou, YR
关键词ambulatory blood pressure monitoring hypertension arotinolol
刊名HYPERTENSION RESEARCH
2001-09-01
24期:5页:605-610
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]BLOOD-PRESSURE ; REPRODUCIBILITY ; COMBINATION ; NIFEDIPINE
英文摘要

To compare the effects of an a, P blocker, arotinolol, in the treatment of essential hypertension between patients with a dipper and those with a non-dipper profile by means of 24-h ambulatory blood pressure monitoring (ABPM), a multicenter single blind parallel trial was carried out in five clinical centers. After a one-week single blind placebo run-in period, the patients underwent ABPM if their clinic diastolic blood pressure (DBP) ranged from 90-109 mmHg and their clinic systolic blood pressure (SBP) was < 180 mmHg. They were divided into two groups according to the absence (non-dipper group, 24 cases) or presence (dipper group, 23 cases) of nocturnal BP reduction greater than or equal to 10% of daytime BP. ABPM was measured again at the end of the active treatment phase. All patients were given Arotinolol 10-20 mg twice daily for 4 weeks. Twenty four-hour systolic and diastolic average BPs (MSBP, MDBP), 24-h systolic and diastolic blood pressure load (LS BID, LDBP), daytime systolic and diastolic average BPs (dMSBP, dMDBP), daytime systolic and diastolic blood pressure load (dLSBP, dLDBP), nighttime systolic and diastolic average Bps (nMSBP, nMDBP) and nighttime systolic and diastolic blood pressure load (nLSBP, nLDBP) were calculated. Arotinolol was effective in 78.2% of dippers and 54.2% of non-dippers, but the difference in effectiveness between these groups was not statistically significant. After treatment, SBP and DBP-including 24-h, daytime and nighttime systolic and diastolic BPs- were significantly reduced in both groups. During the daytime period, the systolic and diastolic blood pressures were significantly reduced in both dippers and non-dippers, while nighttime systolic and diastolic blood pressures were significantly reduced only in the non-dipper group. No significant changes were found in the dipper group over this period. In conclusion, Arotinolol, which can be dosed twice daily, is an effective antihypertensive agent which effectively lowers blood pressure during the day while reducing nighttime blood pressure more in non-dippers than in dippers, without excessive lowering blood pressure in the latter.

语种英语
WOS记录号WOS:000171603100021
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59829
Collection北京大学第二临床医学院
作者单位1.Beijing Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Anzhen Hosp, Beijing, Peoples R China
3.Beijing Univ, Hosp 1, Beijing 100871, Peoples R China
4.Fu Wai Hosp, Chinese Acad Med Sci, Beijing 100037, Peoples R China
5.PUMC, Beijing 100037, Peoples R China
Recommended Citation
GB/T 7714
Wu, HY,Zhang, YQ,Huang, HF,et al. Clinical trial of arotinolol in the treatment of hypertension: Dippers vs. non-dippers[J]. HYPERTENSION RESEARCH,2001,24(5):605-610.
APA Wu, HY.,Zhang, YQ.,Huang, HF.,Zhang, YH.,Liu, GZ.,...&Zhou, YR.(2001).Clinical trial of arotinolol in the treatment of hypertension: Dippers vs. non-dippers.HYPERTENSION RESEARCH,24(5),605-610.
MLA Wu, HY,et al."Clinical trial of arotinolol in the treatment of hypertension: Dippers vs. non-dippers".HYPERTENSION RESEARCH 24.5(2001):605-610.
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