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Triterpene Saponins from the Roots of Ilex asprella
Lei, Yu1,2; Shi, She-Po3; Song, Yue-Lin1; Bi, Dan1; Tu, Peng-Fei1
关键词Triterpene Saponins Ilex Asprella Saponins Ilexasprellanosides A-f Cytotoxic Activity
刊名CHEMISTRY & BIODIVERSITY
2014-05-01
DOI10.1002/cbdv.201300155
11期:5页:767-775
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
资助者National Natural Science Foundation of China ; Program for the Significant New Formulation of New Drugs ; National Natural Science Foundation of China ; Program for the Significant New Formulation of New Drugs
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]GLYCOSIDES ; LEAVES
英文摘要

Six new triterpene saponins, ilexasprellanosides A-F (1-6, resp.), together with eleven known compounds were isolated from the roots of Ilex asprella. The new saponins were characterized as ursa-12,18-dien-28-oic acid 3-O--D-xylopyranoside (1), 19-hydroxyursolic acid 3-O--D-(2-O-acetylxylopyranoside) (2), 19-hydroxyursolic acid 3-O--D-glucuronopyranoside (3), 3,19-dihydroxyolean-12-en-23,28-dioic acid 28-O--D-glucopyranoside (4), 19-hydroxyoleanolic acid 3-O--D-(2-O-acetylxylopyranoside) (5), 19-hydroxyoleanolic acid 3-O--D-glucuronopyranoside (6). The structures of the new compounds were elucidated by analysis of their spectroscopic data and chemical degradation. Compounds 2, 4, oleanolic acid 3-O--D-glucuronopyranoside, 3--acetoxy-28-hydroxyurs-12-ene, and pomolic acid showed significant cytotoxic activities against human tumor cell line A549 (IC50 values of 1.87, 2.51, 1.41, 3.24, and 5.63M, resp.).

语种英语
所属项目编号30672608 ; 2009ZX09311-004
资助者National Natural Science Foundation of China ; Program for the Significant New Formulation of New Drugs ; National Natural Science Foundation of China ; Program for the Significant New Formulation of New Drugs
WOS记录号WOS:000336376200008
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59833
Collection北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Lab Anim Ctr, Beijing 100871, Peoples R China
3.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Lei, Yu,Shi, She-Po,Song, Yue-Lin,et al. Triterpene Saponins from the Roots of Ilex asprella[J]. CHEMISTRY & BIODIVERSITY,2014,11(5):767-775.
APA Lei, Yu,Shi, She-Po,Song, Yue-Lin,Bi, Dan,&Tu, Peng-Fei.(2014).Triterpene Saponins from the Roots of Ilex asprella.CHEMISTRY & BIODIVERSITY,11(5),767-775.
MLA Lei, Yu,et al."Triterpene Saponins from the Roots of Ilex asprella".CHEMISTRY & BIODIVERSITY 11.5(2014):767-775.
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