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学科主题: 临床医学
题名:
Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly
作者: Wang, Wei1; Zhang, Ning1; Zhu, Xu-Hui1; He, Zhi-Song2; Wahafu, Wasilijiang2; Xu, Zhi-Qing3; Yang, Yong1
关键词: tumour necrosis factor-like ligand 1A ; vascular endothelial cell growth inhibitor ; death-domain receptor 3 ; bladder ischaemia ; lower urinary tract symptoms ; aging bladder
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2012-08-01
DOI: 10.3892/mmr.2012.928
卷: 6, 期:2, 页:434-438
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: NERVE GROWTH-FACTOR ; VON-WILLEBRAND-FACTOR ; GENE-EXPRESSION ; BOWEL-DISEASE ; CELL ; INHIBITION ; CYTOKINE ; VEGI ; OVERACTIVITY ; PATHOGENESIS
英文摘要:

Benign prostatic hyperplasia often causes intravesical obstruction in elderly men; however, the processes of aging and bladder outlet obstruction independently evoke alterations in the structure and function of the bladder. These changes lead to lower urinary tract symptoms; however, it is difficult to separate the effects of prostatic obstruction on the bladder from those of aging. Nevertheless, few studies have focused on elucidating the pathophysiological mechanisms in the aged bladder. Bladder dysfunction due to detrusor instabitliy (caused by old age) is considered to be associated with chronic ischaemia and inflammation. The aim of this study was to explore the role of tumour necrosis factor (TNF)-like ligand 1A (TL1A) and death-domain receptor (DR)3 in the ischaemic and inflammatory process of aged bladder dysfunction. Sixteen bladder tissue samples collected from patients with urothelial tumours of the bladder were divided into two groups according to age: group 1 (controls, n=8) and group 2 (aged group, n=8). Urodynamic examinations were preformed before radical cystectomy. The full-thickness bladder tissues were obtained at least 5 cm away from the margin of the tumours. The mRNA expression levels of TL1A, DR3, von Willebrand factor (vWF), interleukin (IL)-6 and nerve growth factor (NGF) in the two groups were determined using real-time reverse transcription-PCR and the protein expression levels of TL1A, DR3 and p65 were determined by western blot analysis. The TL1A and DR3 mRNA and protein expression levels of the aged bladders were upregulated compared to the control group (p<0.05). Compared to the control, the mRNA expression levels of vWF in the aged bladder tissues were markedly lower (p<0.01); however, the mRNA expression levels of IL-6 were significantly higher in the aged bladder tissues (p<0.01) compared to the control. No significant difference in NGF mRNA expression between the two groups was detected (p>0.05). In conclusion, the aged bladder was associated with ischaemic and inflammatory alterations in comparison to the control group. TL1A and DR3 may play an important role in the pathophysiological process of the aged bladder.

语种: 英语
所属项目编号: 7102061
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000305927700032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59835
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Capital Med Univ, Dept Urol, Beijing Chao Yang Hosp, Beijing 100020, Peoples R China
2.Peking Univ, Inst Urol, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
3.Capital Med Univ, Beijing Inst Neurosci, Beijing Key Lab Neural Regenerat & Repair, Beijing 100069, Peoples R China

Recommended Citation:
Wang, Wei,Zhang, Ning,Zhu, Xu-Hui,et al. Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly[J]. MOLECULAR MEDICINE REPORTS,2012,6(2):434-438.
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