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学科主题临床医学
Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly
Wang, Wei1; Zhang, Ning1; Zhu, Xu-Hui1; He, Zhi-Song2; Wahafu, Wasilijiang2; Xu, Zhi-Qing3; Yang, Yong1
关键词tumour necrosis factor-like ligand 1A vascular endothelial cell growth inhibitor death-domain receptor 3 bladder ischaemia lower urinary tract symptoms aging bladder
刊名MOLECULAR MEDICINE REPORTS
2012-08-01
DOI10.3892/mmr.2012.928
6期:2页:434-438
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
资助者Beijing Natural Science Foundation ; Beijing Natural Science Foundation
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]NERVE GROWTH-FACTOR ; VON-WILLEBRAND-FACTOR ; GENE-EXPRESSION ; BOWEL-DISEASE ; CELL ; INHIBITION ; CYTOKINE ; VEGI ; OVERACTIVITY ; PATHOGENESIS
英文摘要

Benign prostatic hyperplasia often causes intravesical obstruction in elderly men; however, the processes of aging and bladder outlet obstruction independently evoke alterations in the structure and function of the bladder. These changes lead to lower urinary tract symptoms; however, it is difficult to separate the effects of prostatic obstruction on the bladder from those of aging. Nevertheless, few studies have focused on elucidating the pathophysiological mechanisms in the aged bladder. Bladder dysfunction due to detrusor instabitliy (caused by old age) is considered to be associated with chronic ischaemia and inflammation. The aim of this study was to explore the role of tumour necrosis factor (TNF)-like ligand 1A (TL1A) and death-domain receptor (DR)3 in the ischaemic and inflammatory process of aged bladder dysfunction. Sixteen bladder tissue samples collected from patients with urothelial tumours of the bladder were divided into two groups according to age: group 1 (controls, n=8) and group 2 (aged group, n=8). Urodynamic examinations were preformed before radical cystectomy. The full-thickness bladder tissues were obtained at least 5 cm away from the margin of the tumours. The mRNA expression levels of TL1A, DR3, von Willebrand factor (vWF), interleukin (IL)-6 and nerve growth factor (NGF) in the two groups were determined using real-time reverse transcription-PCR and the protein expression levels of TL1A, DR3 and p65 were determined by western blot analysis. The TL1A and DR3 mRNA and protein expression levels of the aged bladders were upregulated compared to the control group (p<0.05). Compared to the control, the mRNA expression levels of vWF in the aged bladder tissues were markedly lower (p<0.01); however, the mRNA expression levels of IL-6 were significantly higher in the aged bladder tissues (p<0.01) compared to the control. No significant difference in NGF mRNA expression between the two groups was detected (p>0.05). In conclusion, the aged bladder was associated with ischaemic and inflammatory alterations in comparison to the control group. TL1A and DR3 may play an important role in the pathophysiological process of the aged bladder.

语种英语
所属项目编号7102061
资助者Beijing Natural Science Foundation ; Beijing Natural Science Foundation
WOS记录号WOS:000305927700032
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59835
专题北京大学第一临床医学院_泌尿外科
作者单位1.Capital Med Univ, Dept Urol, Beijing Chao Yang Hosp, Beijing 100020, Peoples R China
2.Peking Univ, Inst Urol, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
3.Capital Med Univ, Beijing Inst Neurosci, Beijing Key Lab Neural Regenerat & Repair, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Wang, Wei,Zhang, Ning,Zhu, Xu-Hui,et al. Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly[J]. MOLECULAR MEDICINE REPORTS,2012,6(2):434-438.
APA Wang, Wei.,Zhang, Ning.,Zhu, Xu-Hui.,He, Zhi-Song.,Wahafu, Wasilijiang.,...&Yang, Yong.(2012).Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly.MOLECULAR MEDICINE REPORTS,6(2),434-438.
MLA Wang, Wei,et al."Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly".MOLECULAR MEDICINE REPORTS 6.2(2012):434-438.
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