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学科主题: 临床医学
题名:
Characteristics of alcoholic liver disease and predictive factors for mortality of patients with alcoholic cirrhosis
作者: Xie, Yan-Di; Feng, Bo; Gao, Yan; Wei, Lai
关键词: alcoholic liver disease ; model for end-stage liver disease ; mortality ; prognostic factors ; risk factors
刊名: HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
发表日期: 2013-12-01
DOI: 10.1016/S1499-3872(13)60094-6
卷: 12, 期:6, 页:594-601
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PROGNOSTIC MODEL ; SURVIVAL ; TRANSPLANTATION ; RISK
英文摘要:

BACKGROUND: Alcoholic liver disease is one of the major chronic liver diseases worldwide. The aim of the study was to describe the clinical characteristics of alcoholic liver disease and to compare the predictive values of biochemical parameters, complications, Child-Turcotte-Pugh score, model for end-stage liver disease (MELD) score and discriminant function score for the mortality of in-hospital or 3-month after discharge of patients with alcoholic cirrhosis (AC).

METHODS: A retrospective record review and statistical analysis were performed on 205 consecutive patients with the discharge diagnosis of alcoholic liver disease. Three models were used to predict the mortality of patients with AC. The number of variceal hemorrhage, infection, hepatic encephalopathy and hepatocellular carcinoma was analyzed as "numbers of complications". Model 1 consisted of creatinine, white blood cell count, international normalized ratio and "numbers of complications". Model 2 consisted of MELD score. Model 3 included "numbers of complications" and MELD score.

RESULTS: The risk of developing AC was significant for patients with alcohol consumption of higher than 80 g/d (OR=2.807, P<0.050) and drinking duration of longer than 10 years (OR=3.429, P<0.028). The area under curve for predicting in-hospital mortality of models 1,2 and 3 was 0.950, 0.886 and 0.911 (all P<0.001), respectively. The area under curve for predicting the 3-month mortality of models 1,2 and 3 was 0.867, 0.878 and 0.893 (all P<0.001), respectively.

CONCLUSIONS: There is a dose-dependent relationship between alcohol consumption and the risk of developing AC. MELD score has a better predictive value than Child-Turcotte-Pugh or discriminant function score for patients with AC, and model 1 or 3 is better than model 2.

语种: 英语
WOS记录号: WOS:000328005900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59836
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100044, Peoples R China

Recommended Citation:
Xie, Yan-Di,Feng, Bo,Gao, Yan,et al. Characteristics of alcoholic liver disease and predictive factors for mortality of patients with alcoholic cirrhosis[J]. HEPATOBILIARY &amp; PANCREATIC DISEASES INTERNATIONAL,2013,12(6):594-601.
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