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学科主题: 临床医学
题名:
Fast and Reliable Determination of Voriconazole in Human Plasma by LC-APCI-MS/MS
作者: Xiong, Xin1,2; Duan, Jingli1; Zhai, Suodi1; Wang, Lijue1; Lan, Xi3
关键词: voriconazole ; liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) ; human plasma
刊名: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
发表日期: 2010-10-01
DOI: 10.1271/bbb.100474
卷: 74, 期:10, 页:2151-2153
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology
关键词[WOS]: TANDEM MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; DOSE-ESCALATION ; ESI-MS ; SERUM ; PHARMACOKINETICS ; QUANTIFICATION ; ELECTROSPRAY ; VALIDATION ; SAMPLES
英文摘要:

A fast and reliable liquid chromatography coupled With atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) method was developed and validated for the quantification of voriconazole in human plasma. The proposed method was validated in a linear range of 50-10,000 ng/ml, and the total run time was 1.5 min. This method was successfully used to support routine therapeutic drug monitoring of voriconazole.

语种: 英语
WOS记录号: WOS:000283624900037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59838
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Pharm, Beijing 100191, Peoples R China
2.Peking Univ, Therapeut Drug Monitoring & Clin Toxicol Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Xiong, Xin,Duan, Jingli,Zhai, Suodi,et al. Fast and Reliable Determination of Voriconazole in Human Plasma by LC-APCI-MS/MS[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,2010,74(10):2151-2153.
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