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学科主题: 临床医学
题名:
Prevalence and associated factors of microalbuminuria in Chinese individuals without diabetes: cross-sectional study
作者: Xiao, Jianzhong1; Xing, Xiaoyan1; Lu, Juming2; Weng, Jianping3; Jia, Weiping4; Ji, Linong5; Shan, Zhongyan6; Liu, Jie7; Tian, Haoming8; Ji, Qiuhe9; Zhu, Dalong10; Ge, Jiapu11; Chen, Gang12; Chen, Li13; Guo, Xiaohui14; Zhao, Zhigang15; Li, Qiang16; Zhou, Zhiguang17; Yang, Zhaojun1; Shan, Guangliang18; He, Jiang19; Yang, Wenying1; China Natl Diabet Metab Disorders
关键词: Microalbuminuria ; Prevalence ; Socioeconomic Status ; Regional Economic Development Level
刊名: BMJ OPEN
发表日期: 2013
DOI: 10.1136/bmjopen-2013-003325
卷: 3, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: URINARY ALBUMIN EXCRETION ; NUTRITION EXAMINATION SURVEY ; CHRONIC KIDNEY-DISEASE ; 3RD NATIONAL-HEALTH ; METABOLIC SYNDROME ; CARDIOVASCULAR EVENTS ; SOCIOECONOMIC-STATUS ; GLUCOSE-TOLERANCE ; CREATININE RATIO ; RISK-FACTORS
英文摘要:

Objective To investigate the prevalence of microalbuminuria (MAU) among Chinese individuals without diabetes and the relationship between MAU and metabolic factors, individual socioeconomic status (SES), and regional economic development level.

Design Cross-sectional study of prevalence of MAU.

Setting 152 urban street districts and 112 rural villages from northeast, north, east, south central, northwest and southwest China.

Participants 46239 participants were recruited using a multistage stratified sampling design from 2007 to 2008. A total of 41290 participants without diabetes determined by oral glucose tolerance test were included in the present study. Urine albumin/creatinine ratio results of 35430 individuals were available.

Primary and secondary outcome measures Positive detection of MAU was determined using an ACR of 22.1-299.9mg/g in men 30.9-299.9mg/g in women.

Results The prevalence of MAU in men was 22.4% and 24.5% in women. In developed, intermediate-developed and under-developed areas, the prevalence of MAU in men was 20.7%, 21.9% and 32.5%, respectively; in women the prevalence was 19.6%, 26.0% and 29.5%, respectively. The prevalence of MAU increased as the number of metabolic disorders present increased, and as the number of lower SES components increased (farmer, below university education level and low income). Prevalence of MAU in developed and intermediate developed areas had adjusted risk ratios of 0.52 (95% CI 0.42 to 0.60) and 0.65 (95% CI 0.57 to 0.76), respectively. Multivariate logistic analyses demonstrated MAU was strongly associated with older age, high-blood pressure, higher blood glucose low education level, low occupational level and residence in under-developed region.

Conclusions Several factors had independent correlations to MAU in China: older age, metabolic abnormalities, lower SES level and living in economically under-developed areas, which encourage the development of strategies to lower the risk for MAU in these susceptible populations.

语种: 英语
所属项目编号: 2011CB504001
项目资助者: Chinese Medical Association Foundation ; Chinese Diabetes Society ; National 973 Programme
WOS记录号: WOS:000329943700056
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59842
Appears in Collections:北京大学第二临床医学院_内分泌科_期刊论文

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作者单位: 1.Shanxi Prov Peoples Hosp, Dept Endocrinol, Taiyuan, Peoples R China
2.Fujian Prov Hosp, Dept Endocrinol, Fuzhou, Peoples R China
3.Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA
4.Japan Friendship Hosp, Dept Endocrinol, Key Lab Diabet Prevent & Control China, Beijing, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
6.Sun Yat Sen Univ, Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
7.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol, Shanghai 200030, Peoples R China
8.Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
9.Chinese Med Univ, Affiliated Hosp 1, Dept Endocrinol, Shenyang, Peoples R China
10.Sichuan Univ, West China Hosp, Dept Endocrinol, Chengdu 610064, Peoples R China
11.Fourth Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian 710032, Peoples R China
12.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Endocrinol, Nanjing 210008, Jiangsu, Peoples R China
13.Xinjiang Uygur Autonomous Reg Hosp, Dept Endocrinol, Urumqi, Peoples R China
14.Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250100, Peoples R China
15.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China
16.Henan Prov Peoples Hosp, Dept Endocrinol, Zhengzhou, Peoples R China
17.Harbin Med Univ, Affiliated Hosp 2, Dept Endocrinol, Harbin, Peoples R China
18.Xiangya Second Hosp, Dept Endocrinol, Changsha, Hunan, Peoples R China
19.Peking Union Med Coll, Dept Epidemiol, Beijing 100021, Peoples R China

Recommended Citation:
Xiao, Jianzhong,Xing, Xiaoyan,Lu, Juming,et al. Prevalence and associated factors of microalbuminuria in Chinese individuals without diabetes: cross-sectional study[J]. BMJ OPEN,2013,3(11).
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