IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients
Liang, Bin1,2; Wang, Shan1,2; Ye, Ying-Liang1,2; Yang, Xiao-Dong1,2; Wang, You-Li1,2; Qu, Jun1,2; Xie, Qi-Wei1,2; Yin, Mu-Jun1,2
关键词colorectal cancer parenteral nutrition omega-3 fatty acids immunomodulation abdominal surgery
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2008-04-21
DOI10.3748/wjg.14.2434
14期:15页:2434-2439
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]MAJOR ABDOMINAL-SURGERY ; SPLANCHNIC BLOOD-FLOW ; FISH-OIL ; OMEGA-3-FATTY-ACIDS IMPROVE ; LEUKOTRIENE SYNTHESIS ; LIPID EMULSIONS ; CRITICALLY-ILL ; RAT MODEL ; GENERATION ; SEPSIS
英文摘要

AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients.

METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT, Intralipid (R), Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven (R), Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-alpha, percentage of CD3(+), CD4(+), and CD8(+) lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications.

RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-alpha, percentage of CD4+, CD8(+) lymphocytes, and ratios of CD4(+)/CD8(+). Compared with those on postoperative d 1, serum IL-6 levels on postoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 +/- 30.53 vs -8.39 +/- 69.08, P = 0.039). Simultaneously, the ratios of CD4(+)/CD8(+) were significantly increased in the FO group (0.92 +/- 0.62 vs 0.25 +/- 1.22, P = 0.035). In addition, depression of serum TNF-alpha levels.(-0.82 +/- 2.71 vs 0.27 +/- 1.67, P = 0.125) and elevation of CD3(+) and CD4(+) lymphocyte percentage (12.85 +/- 11.61 vs 3.84 +/- 19.62, P = 0.081, 17.80 +/- 10.86 vs 9.66 +/- 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 +/- 4.80 d vs 19.62 +/- 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications.

CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response, (c) 2008 WJG. All rights reserved.

语种英语
WOS记录号WOS:000255252700024
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59843
Collection北京大学第二临床医学院
作者单位1.Peking Univ, Div Gastroenterol Surg, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Div Surg Oncol, Peoples Hosp, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Liang, Bin,Wang, Shan,Ye, Ying-Liang,et al. Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(15):2434-2439.
APA Liang, Bin.,Wang, Shan.,Ye, Ying-Liang.,Yang, Xiao-Dong.,Wang, You-Li.,...&Yin, Mu-Jun.(2008).Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients.WORLD JOURNAL OF GASTROENTEROLOGY,14(15),2434-2439.
MLA Liang, Bin,et al."Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients".WORLD JOURNAL OF GASTROENTEROLOGY 14.15(2008):2434-2439.
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