学科主题基础医学
Expressional and functional studies of CKLF1 during dendritic cell maturation
Shao, Luning1; Li, Ting1; Mo, Xiaoning1; Majdic, Otto2; Zhang, Yanfei1; Seyerl, Maria2; Schrauf, Catharina2; Ma, Dalong1; Stoeck, Johannes2; Han, Wenling1
关键词Chemokine-like factor 1 Dendritic cell IFN-gamma HLA-DR IL-12
刊名CELLULAR IMMUNOLOGY
2010
DOI10.1016/j.cellimm.2010.03.015
263期:2页:188-195
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]CHEMOKINE-LIKE FACTOR-1 ; ADAPTIVE IMMUNE-RESPONSES ; TOLL-LIKE RECEPTORS ; RHEUMATOID-ARTHRITIS ; EVOLVING CONCEPTS ; KAPPA-B ; GM-CSF ; ACTIVATION ; ANTIGEN ; PRECURSORS
英文摘要

Chemokine-like factor 1 (CKLF1) was the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family to be discovered. Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the expression and function of CKLF1 in dendritic cells (DCs), which are the most potent antigen-presenting cells In the present study, we showed that CKLF1 was highly expressed in monocytes During differentiation from monocytes to immature DCs. CKLF1 was increased dramatically on day 2 and then decreased from day 3 to 5. Upon maturation with different stimuli, CKLF1 was down-regulated Two peptides of CKLF1, C19 and C27. stimulated the effect of immature DCs (imDCs) on T-cell proliferation and IFN-gamma production. Further study on DC maturation showed that C19 and C27 up-regulated HLA-DR expression and IL-12 secretion, with no obvious effects on CD80, CD83 or CD86 Thus, CKLF1-C19 and -C27 can stimulate antigen-presenting capability of imDCs Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000278666800009
项目编号30671906 ; 2006AA02A305 ; 2009ZX09103-724 ; FWF-APP20266
资助机构National Natural Science Foundation of China ; National High Technology Research and Development Program of China (863 Program) ; National Key New Drug Creation Program of China ; Austrian Science Foundation
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59846
专题北京大学基础医学院_北京大学人类疾病基因研究中心
北京大学基础医学院
北京大学第三临床医学院_儿科
作者单位1.Peking Univ, Ctr Human Dis Genom, Dept Immunol, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Med Univ Vienna, Inst Immunol, Vienna, Austria
推荐引用方式
GB/T 7714
Shao, Luning,Li, Ting,Mo, Xiaoning,et al. Expressional and functional studies of CKLF1 during dendritic cell maturation[J]. CELLULAR IMMUNOLOGY,2010,263(2):188-195.
APA Shao, Luning.,Li, Ting.,Mo, Xiaoning.,Majdic, Otto.,Zhang, Yanfei.,...&Han, Wenling.(2010).Expressional and functional studies of CKLF1 during dendritic cell maturation.CELLULAR IMMUNOLOGY,263(2),188-195.
MLA Shao, Luning,et al."Expressional and functional studies of CKLF1 during dendritic cell maturation".CELLULAR IMMUNOLOGY 263.2(2010):188-195.
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