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学科主题: 基础医学
题名:
Expressional and functional studies of CKLF1 during dendritic cell maturation
作者: Shao, Luning1; Li, Ting1; Mo, Xiaoning1; Majdic, Otto2; Zhang, Yanfei1; Seyerl, Maria2; Schrauf, Catharina2; Ma, Dalong1; Stoeck, Johannes2; Han, Wenling1
关键词: Chemokine-like factor 1 ; Dendritic cell ; IFN-gamma ; HLA-DR ; IL-12
刊名: CELLULAR IMMUNOLOGY
发表日期: 2010
DOI: 10.1016/j.cellimm.2010.03.015
卷: 263, 期:2, 页:188-195
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: CHEMOKINE-LIKE FACTOR-1 ; ADAPTIVE IMMUNE-RESPONSES ; TOLL-LIKE RECEPTORS ; RHEUMATOID-ARTHRITIS ; EVOLVING CONCEPTS ; KAPPA-B ; GM-CSF ; ACTIVATION ; ANTIGEN ; PRECURSORS
英文摘要:

Chemokine-like factor 1 (CKLF1) was the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family to be discovered. Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the expression and function of CKLF1 in dendritic cells (DCs), which are the most potent antigen-presenting cells In the present study, we showed that CKLF1 was highly expressed in monocytes During differentiation from monocytes to immature DCs. CKLF1 was increased dramatically on day 2 and then decreased from day 3 to 5. Upon maturation with different stimuli, CKLF1 was down-regulated Two peptides of CKLF1, C19 and C27. stimulated the effect of immature DCs (imDCs) on T-cell proliferation and IFN-gamma production. Further study on DC maturation showed that C19 and C27 up-regulated HLA-DR expression and IL-12 secretion, with no obvious effects on CD80, CD83 or CD86 Thus, CKLF1-C19 and -C27 can stimulate antigen-presenting capability of imDCs Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30671906 ; 2006AA02A305 ; 2009ZX09103-724 ; FWF-APP20266
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China (863 Program) ; National Key New Drug Creation Program of China ; Austrian Science Foundation
WOS记录号: WOS:000278666800009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59846
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Dept Immunol, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Med Univ Vienna, Inst Immunol, Vienna, Austria

Recommended Citation:
Shao, Luning,Li, Ting,Mo, Xiaoning,et al. Expressional and functional studies of CKLF1 during dendritic cell maturation[J]. CELLULAR IMMUNOLOGY,2010,263(2):188-195.
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