IR@PKUHSC  > 北京大学基础医学院
学科主题临床医学
Malignant hypertension in IgA nephropathy was not associated with background pathological phenotypes of glomerular lesions
Jiang, Lei; Zhang, Jun-jun; Lv, Ji-cheng; Liu, Gang; Zou, Wan-zhong; Zhao, Ming-hui; Zhang, Hong
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2008-12-01
DOI10.1093/ndt/gfn371
23期:12页:3921-3927
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]ANTIENDOTHELIAL CELL ANTIBODIES ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ENDOTHELIAL-CELLS ; VASCULITIS ; AUTOANTIBODIES ; PROGNOSIS
英文摘要

Background. It was reported that IgA nephropathy (IgAN) was the major cause of secondary malignant hypertension (MHT). However, the pathogenesis of MHT secondary to IgAN (IgAN-MHT) is unknown and its association with glomerular pathological phenotypes remains inconclusive. The present study aimed to investigate whether glomerular pathological phenotypes and anti-endothelial cell antibodies (AECA) were associated with the occurrence of IgAN-MHT.

Methods. The glomerular pathological phenotypes of 45 patients with IgAN-MHT were analysed using Haas′ histologic grading system of IgAN. Sera were collected from 34 of the 45 patients with IgAN-MHT, 19 patients with primary MHT, 41 patients with non-MHT IgAN and 10 healthy volunteers. AECA of both IgG and IgA isotypes were detected by western blot analysis using human umbilical vein endothelial cell lysate as antigen.

Results. In the 45 patients with IgAN-MHT, 7 (15.56%), 5 (11.11%), 13 (28.89%), 9 (20%) and 11 (24.44%) patients were graded as Hass I, II, III, IV and V, respectively. Although the severity of non-ischaemic sclerosis, crescents and mesangial proliferation were significantly different between patients with different grades, the levels of blood pressure, SCr and proteinuria at presentation were comparable. Eleven and four protein bands of endothelial proteins could be blotted by AECA-IgG and AECA-IgA in sera from patients with IgAN-MHT. The prevalences of anti-121 kD AECA-IgG (15/34) and anti-92 kD AECA-IgA (10/34) in IgAN-MHT were significantly higher than that of primary MHT, non-MHT IgAN and normal controls, respectively. Patients with anti-92 kD AECA-IgA had more severe glomerular ischaemic sclerosis (6.25-92.86%, median 39.61%) than those without (0-91.67%, median 18.18%, P = 0.035). There was no significant difference in the prevalence of AECA between IgAN-MHT patients with different background glomerular lesions. Only one IgAN patient with MHT was found with both anti-121 kD AECA-IgG and anti-92 kD AECA-IgA. No particular manifestations were found.

Conclusions. The occurrence of IgAN-MHT was not associated with the background glomerular pathological phenotypes of IgAN. AECA might play a role in the pathogenesis of IgAN-MHT.

语种英语
WOS记录号WOS:000261170100030
项目编号30670981 ; 985-2-007-113
资助机构National Nature Science Foundation of China ; Foundation of Ministry of Education, People&prime ; s Republic of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59847
专题北京大学基础医学院
北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Div Renal, Hosp 1, Inst Nephrol,Key Lab Reanl Dis,Minist Hlth China, Beijing 100034, Peoples R China
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GB/T 7714
Jiang, Lei,Zhang, Jun-jun,Lv, Ji-cheng,et al. Malignant hypertension in IgA nephropathy was not associated with background pathological phenotypes of glomerular lesions[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2008,23(12):3921-3927.
APA Jiang, Lei.,Zhang, Jun-jun.,Lv, Ji-cheng.,Liu, Gang.,Zou, Wan-zhong.,...&Zhang, Hong.(2008).Malignant hypertension in IgA nephropathy was not associated with background pathological phenotypes of glomerular lesions.NEPHROLOGY DIALYSIS TRANSPLANTATION,23(12),3921-3927.
MLA Jiang, Lei,et al."Malignant hypertension in IgA nephropathy was not associated with background pathological phenotypes of glomerular lesions".NEPHROLOGY DIALYSIS TRANSPLANTATION 23.12(2008):3921-3927.
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