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Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion
Ge Chang-jiang1; Lu Shu-zheng1; Feng Li-xia1; Huo Yong2; Song Xian-tao1; Chen Xin1; Meng Kang1; Yuan Fei1
关键词Cystatin c Coronary Artery Disease Borderline Coronary Lesion
刊名CHINESE MEDICAL JOURNAL
2012-07-20
DOI10.3760/cma.j.issn.0366-6999.2012.14.014
125期:14页:2472-2476
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INTRAVASCULAR ULTRASOUND ; DEFICIENT MICE ; DISEASE ; ATHEROSCLEROSIS ; INFLAMMATION ; PLAQUE
英文摘要

Background The plasma cystatin C concentration (PcyC) has been demonstrated to have prognostic value in acute coronary syndrome, but the study of PcyC in patients with borderline coronary lesions is limited. Moreover, the effects of atorvastatin and probucol on PcyC and the severity of coronary lesions are unknown. This study was to evaluate the effects of the combination of atorvastatin and probucol on PcyC and severity of coronary lesion in patients with borderline coronary lesions.

Methods One hundred and thirty consecutive patients with borderline coronary lesions (40% to 60% isolated single stenosis assessed by quantitative coronary angiography) were enrolled into the borderline coronary lesion (BCL) group, and one hundred and thirty-six subjects without coronary lesions comprised the controls (CTR). The subjects in the BCL group were randomized into routine treatment (RTT, n=60), and combined treatment with atorvastatin 20 mg plus probucol 1.0 g daily added to routine medication (CBT, n=70), both groups were treated for 6 months continuously. The levels of PcyC, high-sensitive C-reactive protein (hs-CRP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were determined. One hundred and four subjects in the BCL group were rechecked by coronary angiography.

Results PcyC levels were significantly higher in the BCL group than in the CTR group; (2003.26 +/- 825.73) ng/ml vs. (1897.83 +/- 664.46) ng/ml (P <0.01). Compared with patients in the RTT group, the levels of PcyC, TC, LDL-C, TG and hs-CRP were significantly lower in the CBT group (P <0.05). Moreover, there was a trend towards a slight decrease in the RTT patients, (54.38 +/- 10.67)% vs. (50.29 +/- 9.89)% (P >0.05), and a significant decrease in the CBT patients, (53.65 +/- 9.48%) vs. (40.38 +/- 12.93)% (P <0.05), in the mean percent stenosis of borderline coronary lesions before and after six months of treatment.

Conclusions Cystatin C played an important role in the development of coronary artery disease, and was associated with the severity of coronary lesions. The combination of atorvastatin and probucol decreased PcyC levels, and could be the treatment of choice. Chin Med J 2012;125(14):2472-2476

语种英语
WOS记录号WOS:000307677600014
项目编号2006BAI01A02 ; SF-2009-I-09 ; 11JL51
资助机构Key Projects in the National Science and Technology Pillar Program ; Capital Medical Development Fund ; Clinical Cooperation Foundation of Capital Medical University
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59849
专题北京大学第一临床医学院_心血管内科
作者单位1.Capital Med Univ, Dept Cardiol, Beijing Anzhen Hosp, Beijing 100029, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Ge Chang-jiang,Lu Shu-zheng,Feng Li-xia,et al. Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion[J]. CHINESE MEDICAL JOURNAL,2012,125(14):2472-2476.
APA Ge Chang-jiang.,Lu Shu-zheng.,Feng Li-xia.,Huo Yong.,Song Xian-tao.,...&Yuan Fei.(2012).Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion.CHINESE MEDICAL JOURNAL,125(14),2472-2476.
MLA Ge Chang-jiang,et al."Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion".CHINESE MEDICAL JOURNAL 125.14(2012):2472-2476.
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