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学科主题: 临床医学
题名:
Pre-clinical atherosclerosis evaluated by carotid artery intimamedia thickness and the risk factors in children
作者: Yang Xiao-zheng; Liu Ying; Mi Jie; Tang Chao-shu; Du Jun-bao
关键词: intima-media thickness ; atherosclerosis ; risk-factors ; children
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2007-03-05
卷: 120, 期:5, 页:359-362
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CORONARY-HEART-DISEASE ; MEDIA THICKNESS ; CARDIOVASCULAR-DISEASE ; MYOCARDIAL-INFARCTION ; ADOLESCENTS ; ADULTS ; MEN
英文摘要:

Background Atherosclerosis as a cardiovascular disease was found to begin even in the fetal period. However, information about risk factors of pre-clinical atherosclerosis in childhood has been limited. Hence, this study was aimed to find out the risk factors of atherosclerosis by measuring the carotid artery intima-media thickness in children. High resolution B-mode ultrasound used to examine the carotid artery intima-media thickness was demonstrated to be useful in finding the early carotid structural changes.

Methods The study included 79 children who were divided into two groups according to their ages: group I consisted of 42 children with ages from 5 to 9 years and group II consisted of 37 children with ages from 10 to 18 years, Among them, 23 had a positive family history for risk, such as hypertension, obesity or dyslipidemia. Blood samples were collected and total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein were assayed. The carotid artery intima-media thickness was measured by ultrasound. Comparisons were done between the two groups using Student′s t tests and Chi-square analysis. Body mass index, blood pressure, levels of lipids, family history and the carotid artery intima-media thickness were calculated by conditional logistic regression analysis.

Results Compared with the children without a positive family history, the incidence of the increased carotid artery intima-media thickness was significantly high (chi(2)=4.364, P < 0.05). There were no statistically significant differences between left and right carotid arteries in carotid artery intima-media thickness (P > 0.05). In this study, diastolic blood pressure and the atherosclerosis index were suggested to be the risk factors to the thickened carotid artery intima-media thickness. In group I the diastolic blood pressure′s odds radio was 1.187 (P=0.035) and the atherosclerosis index odds radio was 37.165 (P=0.001); in group II the diastolic blood pressure′s odds radio was 1.371 (P=0.009) and the atherosclerosis index odds radio was 30.724 (P=0.015).

Conclusion The diastolic blood pressure and atherosclerosis index were the risk factors in pre-clinical arthrosclerosis. Regularly monitoring the high-risk children for the development and progression of vascular lesion would be of great value in avoiding and preventing cardiovascular disease.

语种: 英语
WOS记录号: WOS:000245020000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59850
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Capital Inst Pediat, Dept Epidemiol, Beijing 100020, Peoples R China
3.Minist Educ Res, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China

Recommended Citation:
Yang Xiao-zheng,Liu Ying,Mi Jie,et al. Pre-clinical atherosclerosis evaluated by carotid artery intimamedia thickness and the risk factors in children[J]. CHINESE MEDICAL JOURNAL,2007,120(5):359-362.
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