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学科主题: 临床医学
题名:
Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia
作者: Wang, G; Dai, J; Mao, JM; Zeng, XK; Yang, XD; Wang, X
关键词: atherosclerosis ; coronary artery disease ; chemokine ; free radicals ; macrophages
刊名: ATHEROSCLEROSIS
发表日期: 2005-04-01
DOI: 10.1016/j.atherosclerosis.2004.10.033
卷: 179, 期:2, 页:395-402
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: IMPROVES ENDOTHELIAL FUNCTION ; CORONARY-ARTERY DISEASE ; CHEMOATTRACTANT PROTEIN-1 ; PLASMA HOMOCYSTEINE ; VASCULAR-DISEASE ; ATHEROSCLEROTIC LESIONS ; MYOCARDIAL-INFARCTION ; ATHEROMATOUS PLAQUES ; RISK FACTOR ; INTERLEUKIN-8
英文摘要:

Our previous study demonstrated that homocysteine (Hcy) mediated the expression and secretion of MCP-1 and IL-8 in human monocytes. In the present study, we investigated whether the responsiveness of isolated nionocytes to lipopolysaccharide (LPS)-induced chemokine secretion was enhanced in patients with hyperhomocysteinemia (HHcy), and if so, whether this enhanced response could be inhibited by folic acid treatment. We studied 38 control subjects and 40 patients with HHcy. The results showed that MCP-1 secretion from isolated monocytes in response to low-dose LPS in patients with HHcy was significantly higher than that in controls. After patients with HHcy underwent low-dose folic acid treatment (0.8 mg/d) for 6 months, plasma Hcy levels were decreased and the hyper-responsiveness of MCP-1 and IL-8 secreted by isolated monocytes was significantly reversed. Furthermore, folic acid treatment at high concentrations (5 mu M) significantly reduced the elevated levels of reactive oxygen species, NADPH oxidase activity and chemokines in response to Hcy in cultured human monocytes. HHcy may contribute to atherogenesis through enhancing the responsiveness of monocytes to inflammatory stimuli and promoting leukocyte recruitment into atherosclerotic plaque. In addition to lowering the plasma levels of Hcy, low-dose folic acid treatment exerts beneficial effects on patients with HHcy by inhibiting pro-inflammatory responses such as chemokine secretion from human rnonocytes. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000228108900025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59854
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Basic Med Coll, Dept Physiol, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Basic Med Coll, Key Lab Mol Cardiovasc Sci,Educ Minist, Beijing 100083, Peoples R China

Recommended Citation:
Wang, G,Dai, J,Mao, JM,et al. Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia[J]. ATHEROSCLEROSIS,2005,179(2):395-402.
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