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Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia
Wang, G; Dai, J; Mao, JM; Zeng, XK; Yang, XD; Wang, X
关键词atherosclerosis coronary artery disease chemokine free radicals macrophages
刊名ATHEROSCLEROSIS
2005-04-01
DOI10.1016/j.atherosclerosis.2004.10.033
179期:2页:395-402
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]IMPROVES ENDOTHELIAL FUNCTION ; CORONARY-ARTERY DISEASE ; CHEMOATTRACTANT PROTEIN-1 ; PLASMA HOMOCYSTEINE ; VASCULAR-DISEASE ; ATHEROSCLEROTIC LESIONS ; MYOCARDIAL-INFARCTION ; ATHEROMATOUS PLAQUES ; RISK FACTOR ; INTERLEUKIN-8
英文摘要

Our previous study demonstrated that homocysteine (Hcy) mediated the expression and secretion of MCP-1 and IL-8 in human monocytes. In the present study, we investigated whether the responsiveness of isolated nionocytes to lipopolysaccharide (LPS)-induced chemokine secretion was enhanced in patients with hyperhomocysteinemia (HHcy), and if so, whether this enhanced response could be inhibited by folic acid treatment. We studied 38 control subjects and 40 patients with HHcy. The results showed that MCP-1 secretion from isolated monocytes in response to low-dose LPS in patients with HHcy was significantly higher than that in controls. After patients with HHcy underwent low-dose folic acid treatment (0.8 mg/d) for 6 months, plasma Hcy levels were decreased and the hyper-responsiveness of MCP-1 and IL-8 secreted by isolated monocytes was significantly reversed. Furthermore, folic acid treatment at high concentrations (5 mu M) significantly reduced the elevated levels of reactive oxygen species, NADPH oxidase activity and chemokines in response to Hcy in cultured human monocytes. HHcy may contribute to atherogenesis through enhancing the responsiveness of monocytes to inflammatory stimuli and promoting leukocyte recruitment into atherosclerotic plaque. In addition to lowering the plasma levels of Hcy, low-dose folic acid treatment exerts beneficial effects on patients with HHcy by inhibiting pro-inflammatory responses such as chemokine secretion from human rnonocytes. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000228108900025
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59854
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Basic Med Coll, Dept Physiol, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Basic Med Coll, Key Lab Mol Cardiovasc Sci,Educ Minist, Beijing 100083, Peoples R China
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GB/T 7714
Wang, G,Dai, J,Mao, JM,et al. Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia[J]. ATHEROSCLEROSIS,2005,179(2):395-402.
APA Wang, G,Dai, J,Mao, JM,Zeng, XK,Yang, XD,&Wang, X.(2005).Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia.ATHEROSCLEROSIS,179(2),395-402.
MLA Wang, G,et al."Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia".ATHEROSCLEROSIS 179.2(2005):395-402.
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