学科主题临床医学
Antiviral action of interferon-alpha against hepatitis C virus replicon and its modulation by interferon-gamma and interleukin-8
Jia, Yintang; Wei, Lai; Jiang, Dong; Wang, Jianghua; Cong, Xu; Fei, Ran
关键词hepatitis C virus replicon interferon-alpha interferon-gamma interleukin-8
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2007-08-01
DOI10.1111/j.1440-1746.2007.04957.x
22期:8页:1278-1285
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]NONSTRUCTURAL 5A PROTEIN ; CELL-CULTURE ; RNA REPLICATION ; PLUS RIBAVIRIN ; EXPRESSION ; INFECTION ; NS5A ; RESISTANCE ; MUTATIONS ; THERAPY
英文摘要

Background and Aim: Interferon-a (IFN-alpha) based therapy is the main treatment used to control hepatitis C virus (HCV) infection. The aim of this study was to understand the mechanisms of IFN-alpha inhibition of HCV replication and the resistance of HCV to IFN-alpha therapy, and improve the efficiency of HCV treatment.

Methods: The inhibitory effects of IFN-a on a HCV replicon system were examined and the potential regulatory effects of interferon-gamma (IFN-gamma) and interleukin-8 (IL-8) on the antiviral actions of IFN-a were also investigated in this report.

Results: The results showed that IFN-alpha can effectively inhibit the replication of HCV replicon. Pretreatment of HCV replicon cells with IFN-gamma could significantly potentiate the inhibitory effects of IFN-alpha on the HCV replicon. Direct addition of IL-8 to the culture medium of HCV replicon cells could partially rescue the HCV replicon from the inhibition of IFN-alpha, which may be the result of IL-8 down-regulation of interferon-stimulated genes.

Conclusion: Our study demonstrated that IFN-gamma has synergistic antiviral effects with IFN-alpha; whereas IL-8 can attenuate the anti-HCV actions of IFN-alpha and is associated with HCV resistance to interferon-alpha therapy.

语种英语
WOS记录号WOS:000248544200022
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59860
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, People Hosp, Inst Hepatol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Jia, Yintang,Wei, Lai,Jiang, Dong,et al. Antiviral action of interferon-alpha against hepatitis C virus replicon and its modulation by interferon-gamma and interleukin-8[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2007,22(8):1278-1285.
APA Jia, Yintang,Wei, Lai,Jiang, Dong,Wang, Jianghua,Cong, Xu,&Fei, Ran.(2007).Antiviral action of interferon-alpha against hepatitis C virus replicon and its modulation by interferon-gamma and interleukin-8.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,22(8),1278-1285.
MLA Jia, Yintang,et al."Antiviral action of interferon-alpha against hepatitis C virus replicon and its modulation by interferon-gamma and interleukin-8".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 22.8(2007):1278-1285.
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