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学科主题: 临床医学
题名:
Antiviral action of interferon-alpha against hepatitis C virus replicon and its modulation by interferon-gamma and interleukin-8
作者: Jia, Yintang; Wei, Lai; Jiang, Dong; Wang, Jianghua; Cong, Xu; Fei, Ran
关键词: hepatitis C virus replicon ; interferon-alpha ; interferon-gamma ; interleukin-8
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2007-08-01
DOI: 10.1111/j.1440-1746.2007.04957.x
卷: 22, 期:8, 页:1278-1285
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: NONSTRUCTURAL 5A PROTEIN ; CELL-CULTURE ; RNA REPLICATION ; PLUS RIBAVIRIN ; EXPRESSION ; INFECTION ; NS5A ; RESISTANCE ; MUTATIONS ; THERAPY
英文摘要:

Background and Aim: Interferon-a (IFN-alpha) based therapy is the main treatment used to control hepatitis C virus (HCV) infection. The aim of this study was to understand the mechanisms of IFN-alpha inhibition of HCV replication and the resistance of HCV to IFN-alpha therapy, and improve the efficiency of HCV treatment.

Methods: The inhibitory effects of IFN-a on a HCV replicon system were examined and the potential regulatory effects of interferon-gamma (IFN-gamma) and interleukin-8 (IL-8) on the antiviral actions of IFN-a were also investigated in this report.

Results: The results showed that IFN-alpha can effectively inhibit the replication of HCV replicon. Pretreatment of HCV replicon cells with IFN-gamma could significantly potentiate the inhibitory effects of IFN-alpha on the HCV replicon. Direct addition of IL-8 to the culture medium of HCV replicon cells could partially rescue the HCV replicon from the inhibition of IFN-alpha, which may be the result of IL-8 down-regulation of interferon-stimulated genes.

Conclusion: Our study demonstrated that IFN-gamma has synergistic antiviral effects with IFN-alpha; whereas IL-8 can attenuate the anti-HCV actions of IFN-alpha and is associated with HCV resistance to interferon-alpha therapy.

语种: 英语
WOS记录号: WOS:000248544200022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59860
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, People Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Jia, Yintang,Wei, Lai,Jiang, Dong,et al. Antiviral action of interferon-alpha against hepatitis C virus replicon and its modulation by interferon-gamma and interleukin-8[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2007,22(8):1278-1285.
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