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学科主题临床医学
Endoplasmic reticulum stress is activated in light-induced retinal degeneration
Yang, Li-ping1; Wu, Le-meng1; Guo, Xiu-juan1; Li, Ying1; Tso, Mark O. M.1,2
关键词apoptosis unfolded protein response GRP78/BiP caspase-12 eIf2 alpha PERK
刊名JOURNAL OF NEUROSCIENCE RESEARCH
2008-03-01
DOI10.1002/jnr.21535
86期:4页:910-919
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]UNFOLDED PROTEIN RESPONSE ; INDUCED PHOTORECEPTOR APOPTOSIS ; ER STRESS ; IN-VIVO ; CELL-DEATH ; CASPASE-12 ; TRANSLATION ; PATHWAY ; MICE ; INHIBITION
英文摘要

Exposure to excessive levels of light induces photoreceptor apoptosis and has previously been used as a model for the study of retinal degeneration. During the light exposure, intracellular calcium levels increase, and reactive oxygen species (ROS) are generated, which have been shown to cause endoplasmic reticulum (ER) stress. In the present study, we investigated the role of ER stress in light-induced photoreceptor apoptosis. Our study demonstrated that, after light exposure, the ER stress sensors including glucose-regulated protein-78 (GRP78/BiP), caspase-12, phospho-eukaryotic initiation factor 2 alpha (eIF2 alpha), and phospho-pancreatic ER kinase (PERK) were significantly up-regulated in a time-dependent manner. The up-regulation of these proteins coincided with or preceded the photoreceptor apoptosis indicated by TUNEL. These data showed that ER stress played an important role in light-induced photoreceptor apoptosis. Therefore, ER stress modulators could be strong candidates as therapeutic agents in the treatment of retinal degenerative diseases. (c) 2007 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000253961700017
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被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59867
专题北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Peking Univ Hosp 3, Peking Univ Eye Ctr, Beijing 100083, Peoples R China
2.Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA
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Yang, Li-ping,Wu, Le-meng,Guo, Xiu-juan,et al. Endoplasmic reticulum stress is activated in light-induced retinal degeneration[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2008,86(4):910-919.
APA Yang, Li-ping,Wu, Le-meng,Guo, Xiu-juan,Li, Ying,&Tso, Mark O. M..(2008).Endoplasmic reticulum stress is activated in light-induced retinal degeneration.JOURNAL OF NEUROSCIENCE RESEARCH,86(4),910-919.
MLA Yang, Li-ping,et al."Endoplasmic reticulum stress is activated in light-induced retinal degeneration".JOURNAL OF NEUROSCIENCE RESEARCH 86.4(2008):910-919.
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