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学科主题: 临床医学
题名:
Endoplasmic reticulum stress is activated in light-induced retinal degeneration
作者: Yang, Li-ping1; Wu, Le-meng1; Guo, Xiu-juan1; Li, Ying1; Tso, Mark O. M.1,2
关键词: apoptosis ; unfolded protein response ; GRP78/BiP ; caspase-12 ; eIf2 alpha ; PERK
刊名: JOURNAL OF NEUROSCIENCE RESEARCH
发表日期: 2008-03-01
DOI: 10.1002/jnr.21535
卷: 86, 期:4, 页:910-919
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: UNFOLDED PROTEIN RESPONSE ; INDUCED PHOTORECEPTOR APOPTOSIS ; ER STRESS ; IN-VIVO ; CELL-DEATH ; CASPASE-12 ; TRANSLATION ; PATHWAY ; MICE ; INHIBITION
英文摘要:

Exposure to excessive levels of light induces photoreceptor apoptosis and has previously been used as a model for the study of retinal degeneration. During the light exposure, intracellular calcium levels increase, and reactive oxygen species (ROS) are generated, which have been shown to cause endoplasmic reticulum (ER) stress. In the present study, we investigated the role of ER stress in light-induced photoreceptor apoptosis. Our study demonstrated that, after light exposure, the ER stress sensors including glucose-regulated protein-78 (GRP78/BiP), caspase-12, phospho-eukaryotic initiation factor 2 alpha (eIF2 alpha), and phospho-pancreatic ER kinase (PERK) were significantly up-regulated in a time-dependent manner. The up-regulation of these proteins coincided with or preceded the photoreceptor apoptosis indicated by TUNEL. These data showed that ER stress played an important role in light-induced photoreceptor apoptosis. Therefore, ER stress modulators could be strong candidates as therapeutic agents in the treatment of retinal degenerative diseases. (c) 2007 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000253961700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59867
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 3, Peking Univ Eye Ctr, Beijing 100083, Peoples R China
2.Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA

Recommended Citation:
Yang, Li-ping,Wu, Le-meng,Guo, Xiu-juan,et al. Endoplasmic reticulum stress is activated in light-induced retinal degeneration[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2008,86(4):910-919.
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