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学科主题临床医学
The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation
Zou, Toujun1,2; Zhen, Mingming1; Chen, Daiqin1,2; Li, Ruimin1,2; Guan, Mirong1,2; Shu, Chunying1; Han, Hongbin3; Wang, Chunru1
刊名DALTON TRANSACTIONS
2015
DOI10.1039/c4dt03482a
44期:19页:9114-9119
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear
研究领域[WOS]Chemistry
关键词[WOS]IMAGING CONTRAST AGENT ; RESONANCE ; RELAXIVITY ; ENHANCEMENT ; AGGREGATION ; COMPLEXES ; TUMORS ; MEDIA ; DYADS ; MICE
英文摘要

Manganese-porphyrin compounds as MRI contrast agents have drawn particular attention due to high relaxivities and unique biodistribution. It has been reported that the charge density of the metal center and steric decompression of the substituents, rather than rotational correlation time, were the key factors to determine the relaxivities of manganese(III) porphyrins. In this study, [6,6]-phenyl-C-61-butyric acid (PC(61)BA) was introduced into 5-(4-aminophenyl)-10,15,20-tris (4-sulfonatophenyl) porphyrin (APTSPP) to investigate the influence on water proton relaxation. The obtained PC(61)BA-APTSPP-Mn possesses a relaxivity of 19.2 mM(-1) s(-1), which is greater than that of Mn-APTSPP (11.2 mM(-1) s(-1)) and clinically used Gd-DTPA (4.1 mM(-1) s(-1)) at 0.5 T, and even more effective compared with those binding manganese(III) porphyrins to certain macromolecules. It was reasonably speculated that the high relaxivity of PC(61)BA-APTSPP-Mn should ascribe to the charge density variation of MnIII and steric decompression induced by PC(61)BA. Both fluorescence emission spectra and cyclic voltammetry results verified the presence of electronic communication between PC(61)BA and APTSPP-Mn. In addition, the hydrodynamic diameter of PC(61)BA-APTSPP-Mn aggregates was much smaller than that of APTSPP-Mn aggregates, which may contribute to the higher relaxivity by inhibiting the formation of dimers of APTSPP-Mn. Therefore, the introduction of fullerene derivatives is suggested to be a good strategy for the improvement of the relaxivities of manganese(III) porphyrins.

语种英语
WOS记录号WOS:000354203400042
项目编号51372251 ; 11179006 ; KGZD-EW-T02
资助机构National Natural Science Foundation of China ; Chinese Academy of Sciences
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59869
专题北京大学第三临床医学院_放射科
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Zou, Toujun,Zhen, Mingming,Chen, Daiqin,et al. The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation[J]. DALTON TRANSACTIONS,2015,44(19):9114-9119.
APA Zou, Toujun.,Zhen, Mingming.,Chen, Daiqin.,Li, Ruimin.,Guan, Mirong.,...&Wang, Chunru.(2015).The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation.DALTON TRANSACTIONS,44(19),9114-9119.
MLA Zou, Toujun,et al."The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation".DALTON TRANSACTIONS 44.19(2015):9114-9119.
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