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学科主题: 临床医学
题名:
The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation
作者: Zou, Toujun1,2; Zhen, Mingming1; Chen, Daiqin1,2; Li, Ruimin1,2; Guan, Mirong1,2; Shu, Chunying1; Han, Hongbin3; Wang, Chunru1
刊名: DALTON TRANSACTIONS
发表日期: 2015
DOI: 10.1039/c4dt03482a
卷: 44, 期:19, 页:9114-9119
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Inorganic & Nuclear
研究领域[WOS]: Chemistry
关键词[WOS]: IMAGING CONTRAST AGENT ; RESONANCE ; RELAXIVITY ; ENHANCEMENT ; AGGREGATION ; COMPLEXES ; TUMORS ; MEDIA ; DYADS ; MICE
英文摘要:

Manganese-porphyrin compounds as MRI contrast agents have drawn particular attention due to high relaxivities and unique biodistribution. It has been reported that the charge density of the metal center and steric decompression of the substituents, rather than rotational correlation time, were the key factors to determine the relaxivities of manganese(III) porphyrins. In this study, [6,6]-phenyl-C-61-butyric acid (PC(61)BA) was introduced into 5-(4-aminophenyl)-10,15,20-tris (4-sulfonatophenyl) porphyrin (APTSPP) to investigate the influence on water proton relaxation. The obtained PC(61)BA-APTSPP-Mn possesses a relaxivity of 19.2 mM(-1) s(-1), which is greater than that of Mn-APTSPP (11.2 mM(-1) s(-1)) and clinically used Gd-DTPA (4.1 mM(-1) s(-1)) at 0.5 T, and even more effective compared with those binding manganese(III) porphyrins to certain macromolecules. It was reasonably speculated that the high relaxivity of PC(61)BA-APTSPP-Mn should ascribe to the charge density variation of MnIII and steric decompression induced by PC(61)BA. Both fluorescence emission spectra and cyclic voltammetry results verified the presence of electronic communication between PC(61)BA and APTSPP-Mn. In addition, the hydrodynamic diameter of PC(61)BA-APTSPP-Mn aggregates was much smaller than that of APTSPP-Mn aggregates, which may contribute to the higher relaxivity by inhibiting the formation of dimers of APTSPP-Mn. Therefore, the introduction of fullerene derivatives is suggested to be a good strategy for the improvement of the relaxivities of manganese(III) porphyrins.

语种: 英语
所属项目编号: 51372251 ; 11179006 ; KGZD-EW-T02
项目资助者: National Natural Science Foundation of China ; Chinese Academy of Sciences
WOS记录号: WOS:000354203400042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59869
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

Recommended Citation:
Zou, Toujun,Zhen, Mingming,Chen, Daiqin,et al. The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation[J]. DALTON TRANSACTIONS,2015,44(19):9114-9119.
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