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学科主题: 临床医学
题名:
5-HTT SS Genotype is Associated with the Pro-nociceptive Sensation by Alcoholic Sting
作者: Nan, Jun1; Yuan, Hu1; Li, Kangjie1; Jin, Yuanzhe2; Yu, Miao3
关键词: Serotonin transporter 5-HTT ; Visual analog scale ; Pain
刊名: CELL BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2014-04-01
DOI: 10.1007/s12013-013-9759-5
卷: 68, 期:3, 页:629-633
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: LONG-TERM POTENTIATION ; GENE REGULATORY REGION ; PERCEPTUAL CORRELATE ; SEROTONIN ; POLYMORPHISM ; HUMANS ; DEPRESSION ; LTP
英文摘要:

The purpose of this study was to examine the relationship between the genetic polymorphism in the promoter of the SLC6A4 gene encoding the serotonin transporter (5-HTT) and the sensitivity to noxious stimulation from a clinical perspective. The genotyping of the 217 outpatients with mild epidermal abrasion in lateral crural region was performed by a combination of polymerase chain reaction and digestion. The intensity of pain to medical alcohol treatment was rated on a visual analog scale (VAS). The results suggest that the human triallelic 5-HTT genotypes are related to individual differences in sensitivity to alcoholic sting. According to the VAS ratings, the subjects with the 5-HTT low-expression genotype reported more pain than those with 5-HTT medium- and high-expression genotypes following test stimuli. There is no significant difference between sexes in the same SLC6A4 genotype and between medium and high expressions of 5-HTT subjects. Taken together, our study supports the hypothesis that the transcription rate of the 5-HTT transporter may play an important role in the pain sensitivity and central sensitization.

语种: 英语
WOS记录号: WOS:000332958100025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59875
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Yanbian Univ Hosp, Dept Spine Surg, Yanji 133002, Jilin, Peoples R China
2.Yanbian Univ, Dept Physiol, Yanji 133002, Jilin, Peoples R China
3.Peking Univ, Hosp 3, Dept Orthoped, Beijing 100191, Peoples R China

Recommended Citation:
Nan, Jun,Yuan, Hu,Li, Kangjie,et al. 5-HTT SS Genotype is Associated with the Pro-nociceptive Sensation by Alcoholic Sting[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2014,68(3):629-633.
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