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5-HTT SS Genotype is Associated with the Pro-nociceptive Sensation by Alcoholic Sting
Nan, Jun1; Yuan, Hu1; Li, Kangjie1; Jin, Yuanzhe2; Yu, Miao3
关键词Serotonin transporter 5-HTT Visual analog scale Pain
刊名CELL BIOCHEMISTRY AND BIOPHYSICS
2014-04-01
DOI10.1007/s12013-013-9759-5
68期:3页:629-633
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]LONG-TERM POTENTIATION ; GENE REGULATORY REGION ; PERCEPTUAL CORRELATE ; SEROTONIN ; POLYMORPHISM ; HUMANS ; DEPRESSION ; LTP
英文摘要

The purpose of this study was to examine the relationship between the genetic polymorphism in the promoter of the SLC6A4 gene encoding the serotonin transporter (5-HTT) and the sensitivity to noxious stimulation from a clinical perspective. The genotyping of the 217 outpatients with mild epidermal abrasion in lateral crural region was performed by a combination of polymerase chain reaction and digestion. The intensity of pain to medical alcohol treatment was rated on a visual analog scale (VAS). The results suggest that the human triallelic 5-HTT genotypes are related to individual differences in sensitivity to alcoholic sting. According to the VAS ratings, the subjects with the 5-HTT low-expression genotype reported more pain than those with 5-HTT medium- and high-expression genotypes following test stimuli. There is no significant difference between sexes in the same SLC6A4 genotype and between medium and high expressions of 5-HTT subjects. Taken together, our study supports the hypothesis that the transcription rate of the 5-HTT transporter may play an important role in the pain sensitivity and central sensitization.

语种英语
WOS记录号WOS:000332958100025
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59875
专题北京大学第三临床医学院_骨科
作者单位1.Yanbian Univ Hosp, Dept Spine Surg, Yanji 133002, Jilin, Peoples R China
2.Yanbian Univ, Dept Physiol, Yanji 133002, Jilin, Peoples R China
3.Peking Univ, Hosp 3, Dept Orthoped, Beijing 100191, Peoples R China
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GB/T 7714
Nan, Jun,Yuan, Hu,Li, Kangjie,et al. 5-HTT SS Genotype is Associated with the Pro-nociceptive Sensation by Alcoholic Sting[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2014,68(3):629-633.
APA Nan, Jun,Yuan, Hu,Li, Kangjie,Jin, Yuanzhe,&Yu, Miao.(2014).5-HTT SS Genotype is Associated with the Pro-nociceptive Sensation by Alcoholic Sting.CELL BIOCHEMISTRY AND BIOPHYSICS,68(3),629-633.
MLA Nan, Jun,et al."5-HTT SS Genotype is Associated with the Pro-nociceptive Sensation by Alcoholic Sting".CELL BIOCHEMISTRY AND BIOPHYSICS 68.3(2014):629-633.
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