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Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together
Zhou, Bin1; Gao, Wenjing1; Lv, Jun1; Yu, Canqing1; Wang, Shengfeng1; Liao, Chunxiao1; Pang, Zengchang2; Cong, Liming3; Dong, Zhong4; Wu, Fan5; Wang, Hua6; Wu, Xianping7; Jiang, Guohong8; Wang, Xiaojie9; Wang, Binyou10; Cao, Weihua1; Li, Liming1
关键词Twins Obesity Heritability Environment Adult
刊名BEHAVIOR GENETICS
2015-07-01
DOI10.1007/s10519-015-9711-0
45期:4页:427-437
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology ; Social Sciences
类目[WOS]Behavioral Sciences ; Genetics & Heredity ; Psychology, Multidisciplinary
研究领域[WOS]Behavioral Sciences ; Genetics & Heredity ; Psychology
关键词[WOS]BODY-MASS INDEX ; TO-HEIGHT RATIO ; CARDIOMETABOLIC RISK-FACTORS ; GENOME-WIDE LINKAGE ; WAIST CIRCUMFERENCE ; CARDIOVASCULAR-DISEASE ; PHYSICAL-ACTIVITY ; SCREENING TOOL ; ADULT TWINS ; HIP RATIO
英文摘要

The relative importance of genetic and environmental influences on obesity-related phenotypes remains unclear, and few studies have targeted the Chinese population. Here, we used Chinese twins reared apart and together to explore genetic and environmental influences on body mass index (BMI), waist circumference (WC) and waist-height ratio (WHtR), further to differentiate phenotype heritability between different age groups and genders separately and to differentiate influences of rearing environment and correlated environment. Phenotype heritability was calculated using the structural equation model in 11,401 twin pairs aged 25-85 years. BMI (0.70, 95 % confidence interval (CI) 0.66-0.74) of the total population was highly heritable, while WC (0.53, 95 %CI 0.50-0.57) and WHtR (0.48, 95 %CI 0.45-0.51) were moderately heritable. Age and gender stratified analyses found higher heritability in the younger group and males than the older group and females. The correlated environment had a greater influence on the phenotypes than the rearing environment, especially on WC and WHtR, indicating that more correlated environment actions should be taken to prevent the rising trend of abdominal obesity.

语种英语
WOS记录号WOS:000355748700005
项目编号01-746 ; 81202264 ; 201002007
资助机构China Medical Board ; National Natural Science Foundation of China ; Specific Research Project of Health Public Service, Ministry of Health, China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59881
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Qingdao Ctr Dis Control & Prevent, Qingdao 266033, Peoples R China
3.Zhejiang Ctr Dis Control & Prevent, Hangzhou 310051, Zhejiang, Peoples R China
4.Beijing Ctr Dis Control & Prevent, Beijing 100013, Peoples R China
5.Shanghai Ctr Dis Control & Prevent, Shanghai 200336, Peoples R China
6.Jiangsu Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China
7.Sichuan Ctr Dis Control & Prevent, Chengdu 610041, Peoples R China
8.Tianjin Ctr Dis Control & Prevent, Tianjin 300011, Peoples R China
9.Qinghai Ctr Dis Control & Prevent, Xining 810007, Peoples R China
10.Harbin Med Univ, Harbin 150081, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Bin,Gao, Wenjing,Lv, Jun,et al. Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together[J]. BEHAVIOR GENETICS,2015,45(4):427-437.
APA Zhou, Bin.,Gao, Wenjing.,Lv, Jun.,Yu, Canqing.,Wang, Shengfeng.,...&Li, Liming.(2015).Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together.BEHAVIOR GENETICS,45(4),427-437.
MLA Zhou, Bin,et al."Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together".BEHAVIOR GENETICS 45.4(2015):427-437.
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