北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together
作者: Zhou, Bin1; Gao, Wenjing1; Lv, Jun1; Yu, Canqing1; Wang, Shengfeng1; Liao, Chunxiao1; Pang, Zengchang2; Cong, Liming3; Dong, Zhong4; Wu, Fan5; Wang, Hua6; Wu, Xianping7; Jiang, Guohong8; Wang, Xiaojie9; Wang, Binyou10; Cao, Weihua1; Li, Liming1
关键词: Twins ; Obesity ; Heritability ; Environment ; Adult
刊名: BEHAVIOR GENETICS
发表日期: 2015-07-01
DOI: 10.1007/s10519-015-9711-0
卷: 45, 期:4, 页:427-437
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology ; Social Sciences
类目[WOS]: Behavioral Sciences ; Genetics & Heredity ; Psychology, Multidisciplinary
研究领域[WOS]: Behavioral Sciences ; Genetics & Heredity ; Psychology
关键词[WOS]: BODY-MASS INDEX ; TO-HEIGHT RATIO ; CARDIOMETABOLIC RISK-FACTORS ; GENOME-WIDE LINKAGE ; WAIST CIRCUMFERENCE ; CARDIOVASCULAR-DISEASE ; PHYSICAL-ACTIVITY ; SCREENING TOOL ; ADULT TWINS ; HIP RATIO
英文摘要:

The relative importance of genetic and environmental influences on obesity-related phenotypes remains unclear, and few studies have targeted the Chinese population. Here, we used Chinese twins reared apart and together to explore genetic and environmental influences on body mass index (BMI), waist circumference (WC) and waist-height ratio (WHtR), further to differentiate phenotype heritability between different age groups and genders separately and to differentiate influences of rearing environment and correlated environment. Phenotype heritability was calculated using the structural equation model in 11,401 twin pairs aged 25-85 years. BMI (0.70, 95 % confidence interval (CI) 0.66-0.74) of the total population was highly heritable, while WC (0.53, 95 %CI 0.50-0.57) and WHtR (0.48, 95 %CI 0.45-0.51) were moderately heritable. Age and gender stratified analyses found higher heritability in the younger group and males than the older group and females. The correlated environment had a greater influence on the phenotypes than the rearing environment, especially on WC and WHtR, indicating that more correlated environment actions should be taken to prevent the rising trend of abdominal obesity.

语种: 英语
所属项目编号: 01-746 ; 81202264 ; 201002007
项目资助者: China Medical Board ; National Natural Science Foundation of China ; Specific Research Project of Health Public Service, Ministry of Health, China
WOS记录号: WOS:000355748700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59881
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Qingdao Ctr Dis Control & Prevent, Qingdao 266033, Peoples R China
3.Zhejiang Ctr Dis Control & Prevent, Hangzhou 310051, Zhejiang, Peoples R China
4.Beijing Ctr Dis Control & Prevent, Beijing 100013, Peoples R China
5.Shanghai Ctr Dis Control & Prevent, Shanghai 200336, Peoples R China
6.Jiangsu Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China
7.Sichuan Ctr Dis Control & Prevent, Chengdu 610041, Peoples R China
8.Tianjin Ctr Dis Control & Prevent, Tianjin 300011, Peoples R China
9.Qinghai Ctr Dis Control & Prevent, Xining 810007, Peoples R China
10.Harbin Med Univ, Harbin 150081, Peoples R China

Recommended Citation:
Zhou, Bin,Gao, Wenjing,Lv, Jun,et al. Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together[J]. BEHAVIOR GENETICS,2015,45(4):427-437.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, Bin]'s Articles
[Gao, Wenjing]'s Articles
[Lv, Jun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, Bin]‘s Articles
[Gao, Wenjing]‘s Articles
[Lv, Jun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace