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学科主题临床医学
Different expression patterns and clinical significance of mAxl and sAxl in systemic lupus erythematosus
Zhu, H.1; Sun, X.1; Zhu, L.1; Hu, F.1; Shi, L.1; Fan, C.2; Li, Z.1; Su, Y.1
关键词Axl receptor tyrosine kinases systemic lupus erythematosus SLEDAI apoptosis anti-dsDNA antibodies
刊名LUPUS
2014-06-01
DOI10.1177/0961203314520839
23期:7页:624-634
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]RECEPTOR TYROSINE KINASE ; APOPTOTIC CELLS ; DISEASE-ACTIVITY ; PLASMA-CONCENTRATIONS ; DENDRITIC CELLS ; IMMUNE-SYSTEM ; SOLUBLE FORM ; CLEARANCE ; AXL ; GAS6
英文摘要

Axl is one of the TAM family members that downregulates activated immune responses to maintain immune homeostasis. We analyzed the expression and clinical relevance of Axl on the surface of CD14+ monocytes/macrophages (mAxl, membrane Axl) and in the plasma (sAxl, soluble Axl) from patients with systemic lupus erythematosus (SLE). Compared to healthy subjects, the concentrations of sAxl were significantly elevated in plasma from SLE patients, while the mAxl expression on CD14+ monocytes/macrophages from SLE patients was significantly downregulated. A series of severe disease clinical manifestations and laboratory features such as presence of autoantibodies, 24-hour proteinuria excretion or SLEDAI >= 10 were associated with decreased mAxl expression on monocytes/macrophages but elevated sAxl levels in plasma. The plasma level of Gas6, the main ligand of Axl, was slightly decreased in SLE patients, and was negatively correlated with anti-dsDNA antibodies and C-reactive protein. SLE patients with SLEDAI >= 10 showed significantly lower Gas6 levels. Our study suggests that abnormal mAxl and sAxl expression may be involved in the imbalance of immune regulation in SLE.

语种英语
WOS记录号WOS:000339103900003
项目编号81172844 ; 2010CB529104
资助机构National Natural Science Foundation of China ; National Basic Research Program of China (973 program)
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59883
专题北京大学第二临床医学院
北京大学第一临床医学院_妇产科
北京大学第二临床医学院_风湿免疫科
北京大学第三临床医学院_血液内科
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Clin Immunol Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Lab Med, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhu, H.,Sun, X.,Zhu, L.,et al. Different expression patterns and clinical significance of mAxl and sAxl in systemic lupus erythematosus[J]. LUPUS,2014,23(7):624-634.
APA Zhu, H..,Sun, X..,Zhu, L..,Hu, F..,Shi, L..,...&Su, Y..(2014).Different expression patterns and clinical significance of mAxl and sAxl in systemic lupus erythematosus.LUPUS,23(7),624-634.
MLA Zhu, H.,et al."Different expression patterns and clinical significance of mAxl and sAxl in systemic lupus erythematosus".LUPUS 23.7(2014):624-634.
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