IR@PKUHSC  > 北京大学临床研究所
学科主题临床医学
Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy
Xu, Qian1; Pan, Jianhong2; Yu, Jingwen3; Liu, Xiaoxia1; Liu, Li1; Zuo, Xialin1; Wu, Ping1; Deng, Houliang1; Zhang, Jingjing1; Ji, Aimin1
关键词Lipoic Acid Methylcobalamin Combination Therapy Diabetic Peripheral Neuropathy Meta-analysis
刊名DIABETES RESEARCH AND CLINICAL PRACTICE
2013-08-01
DOI10.1016/j.diabres.2013.03.033
101期:2页:99-105
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]PROTEIN-KINASE-C ; NERVE-CONDUCTION ; OXIDATIVE STRESS ; BLOOD-FLOW ; ENERGY-METABOLISM ; NITRIC-OXIDE ; POLYNEUROPATHY ; PATHOGENESIS ; SEVERITY ; CRITERIA
英文摘要

Aims: To compare the efficacy and safety of daily lipoic acid (300-600 mg i.v.) plus methylcobalamin (500-1000 mg i.v. or im.) (LA-MC) with that of methylcobalamin alone (MC) on diabetic peripheral neuropathy (DPN).

Methods: Electronic database were searched for studies published up to November 1, 2012 and study quality was assessed in duplicate. A random or a fixed effect model was used to analyse outcomes which were expressed as risk ratios (RRs) or mean difference (MD). I-2 statistic was used to assess heterogeneity.

Results: Seventeen studies were included. Combined data from all studies showed that the LA-MC combination therapy was significantly superior to MC monotherapy (RR = 1.47; 95% CI: 1.37-1.58). Superiority of the LA-MC combination was shown in nerve conduction velocity (NCV) with WMDs of 6.89 (95% CI: 4.24-9.73) for median motor nerve conduction velocity (MNCV), 5.24 (4.14-6.34) for median sensory nerve conduction velocity (SNCV), 4.34 (3.03-5.64) for peroneal MNCV, and 4.53 (3.2-5.85) for peroneal SNCV. There were no serious adverse events associated with treatment.

Conclusions: The results of the meta-analysis show that treatment with LA-MC for 2-4 weeks is associated with better outcomes in NCV and neuropathic symptoms relative to MC treatment. However larger well-designed studies are required to confirm this conclusion. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000324160600002
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59893
专题北京大学临床研究所
作者单位1.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China
2.Peoples Hosp Hainan Prov, Dept Endocrinol, Haikou, Peoples R China
3.Southern Med Univ, Zhu Jiang Hosp, Dept Pharm, Guangzhou 510282, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Xu, Qian,Pan, Jianhong,Yu, Jingwen,et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2013,101(2):99-105.
APA Xu, Qian.,Pan, Jianhong.,Yu, Jingwen.,Liu, Xiaoxia.,Liu, Li.,...&Ji, Aimin.(2013).Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy.DIABETES RESEARCH AND CLINICAL PRACTICE,101(2),99-105.
MLA Xu, Qian,et al."Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy".DIABETES RESEARCH AND CLINICAL PRACTICE 101.2(2013):99-105.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Qian]的文章
[Pan, Jianhong]的文章
[Yu, Jingwen]的文章
百度学术
百度学术中相似的文章
[Xu, Qian]的文章
[Pan, Jianhong]的文章
[Yu, Jingwen]的文章
必应学术
必应学术中相似的文章
[Xu, Qian]的文章
[Pan, Jianhong]的文章
[Yu, Jingwen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。