|Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy|
|Xu, Qian1; Pan, Jianhong2; Yu, Jingwen3; Liu, Xiaoxia1; Liu, Li1; Zuo, Xialin1; Wu, Ping1; Deng, Houliang1; Zhang, Jingjing1; Ji, Aimin1|
|关键词||Lipoic Acid Methylcobalamin Combination Therapy Diabetic Peripheral Neuropathy Meta-analysis|
|刊名||DIABETES RESEARCH AND CLINICAL PRACTICE|
|WOS标题词||Science & Technology|
|类目[WOS]||Endocrinology & Metabolism|
|研究领域[WOS]||Endocrinology & Metabolism|
|关键词[WOS]||PROTEIN-KINASE-C ; NERVE-CONDUCTION ; OXIDATIVE STRESS ; BLOOD-FLOW ; ENERGY-METABOLISM ; NITRIC-OXIDE ; POLYNEUROPATHY ; PATHOGENESIS ; SEVERITY ; CRITERIA|
Aims: To compare the efficacy and safety of daily lipoic acid (300-600 mg i.v.) plus methylcobalamin (500-1000 mg i.v. or im.) (LA-MC) with that of methylcobalamin alone (MC) on diabetic peripheral neuropathy (DPN).
Methods: Electronic database were searched for studies published up to November 1, 2012 and study quality was assessed in duplicate. A random or a fixed effect model was used to analyse outcomes which were expressed as risk ratios (RRs) or mean difference (MD). I-2 statistic was used to assess heterogeneity.
Results: Seventeen studies were included. Combined data from all studies showed that the LA-MC combination therapy was significantly superior to MC monotherapy (RR = 1.47; 95% CI: 1.37-1.58). Superiority of the LA-MC combination was shown in nerve conduction velocity (NCV) with WMDs of 6.89 (95% CI: 4.24-9.73) for median motor nerve conduction velocity (MNCV), 5.24 (4.14-6.34) for median sensory nerve conduction velocity (SNCV), 4.34 (3.03-5.64) for peroneal MNCV, and 4.53 (3.2-5.85) for peroneal SNCV. There were no serious adverse events associated with treatment.
Conclusions: The results of the meta-analysis show that treatment with LA-MC for 2-4 weeks is associated with better outcomes in NCV and neuropathic symptoms relative to MC treatment. However larger well-designed studies are required to confirm this conclusion. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
|作者单位||1.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China|
2.Peoples Hosp Hainan Prov, Dept Endocrinol, Haikou, Peoples R China
3.Southern Med Univ, Zhu Jiang Hosp, Dept Pharm, Guangzhou 510282, Guangdong, Peoples R China
|Xu, Qian,Pan, Jianhong,Yu, Jingwen,et al. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2013,101(2):99-105.|
|APA||Xu, Qian.,Pan, Jianhong.,Yu, Jingwen.,Liu, Xiaoxia.,Liu, Li.,...&Ji, Aimin.(2013).Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy.DIABETES RESEARCH AND CLINICAL PRACTICE,101(2),99-105.|
|MLA||Xu, Qian,et al."Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy".DIABETES RESEARCH AND CLINICAL PRACTICE 101.2(2013):99-105.|