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Effect of lanthanum(III) on cytosolic free calcium in isolated rabbit mature osteoclasts
Zhang, JC; Zhang, TL; Xu, SJ; Wang, K; Yu, SF; Yang, MS
关键词lanthanum(Iff) osteoclasts cytosolic free calcium fluo-3/AM rare earths
刊名JOURNAL OF RARE EARTHS
2005-10-01
23期:5页:580-583
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied
研究领域[WOS]Chemistry
关键词[WOS]IN-VITRO ; BONE-RESORPTION ; EXTRACELLULAR CALCIUM ; CELLS
英文摘要

The effect of lanthanum(III) (La3+) on cytosolic free calcium ([Ca2+ ](i)) in isolated rabbit mature osteoclasts was studied with the employment of fluo-3/AM as an intracellular calcium-sensitive fluorescent probe by using a confocal laser scanning microscope. La3+ does not alter basal [ Ca2+] i levels and cell spread area at the concentration of 1.00 x 10(-8) mol (.) L-1. However La3+ at higher concentrations ( 1.00 x 10(-5) and 1.00 x 10(-1) mol (.) L-1) decreases [Ca2+]i levels and cell spread area, and greater decreases are observed for the higher concentrations of La3+. Since [Ca2+], affects cytoskeleton and the adhesion properties of osteoclasts, our results seem to suggest that La3+ inhibit bone resorption by decreasing [Ca2+]i in rabbit mature osteoclasts.

语种英语
WOS记录号WOS:000233064400015
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59897
专题北京大学药学院_化学生物学系
作者单位1.Hebei Univ, Dept Chem, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
3.Capital Univ Med Sci, Sch Pharmaceut Sci, Beijing 100054, Peoples R China
4.Peking Univ, Stomatol Hosp, Dept Oral Pathol, Beijing 100081, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Zhang, JC,Zhang, TL,Xu, SJ,et al. Effect of lanthanum(III) on cytosolic free calcium in isolated rabbit mature osteoclasts[J]. JOURNAL OF RARE EARTHS,2005,23(5):580-583.
APA Zhang, JC,Zhang, TL,Xu, SJ,Wang, K,Yu, SF,&Yang, MS.(2005).Effect of lanthanum(III) on cytosolic free calcium in isolated rabbit mature osteoclasts.JOURNAL OF RARE EARTHS,23(5),580-583.
MLA Zhang, JC,et al."Effect of lanthanum(III) on cytosolic free calcium in isolated rabbit mature osteoclasts".JOURNAL OF RARE EARTHS 23.5(2005):580-583.
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