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学科主题: 药学
题名:
Effect of lanthanum(III) on cytosolic free calcium in isolated rabbit mature osteoclasts
作者: Zhang, JC; Zhang, TL; Xu, SJ; Wang, K; Yu, SF; Yang, MS
关键词: lanthanum(Iff) ; osteoclasts ; cytosolic free calcium ; fluo-3/AM ; rare earths
刊名: JOURNAL OF RARE EARTHS
发表日期: 2005-10-01
卷: 23, 期:5, 页:580-583
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied
研究领域[WOS]: Chemistry
关键词[WOS]: IN-VITRO ; BONE-RESORPTION ; EXTRACELLULAR CALCIUM ; CELLS
英文摘要:

The effect of lanthanum(III) (La3+) on cytosolic free calcium ([Ca2+ ](i)) in isolated rabbit mature osteoclasts was studied with the employment of fluo-3/AM as an intracellular calcium-sensitive fluorescent probe by using a confocal laser scanning microscope. La3+ does not alter basal [ Ca2+] i levels and cell spread area at the concentration of 1.00 x 10(-8) mol (.) L-1. However La3+ at higher concentrations ( 1.00 x 10(-5) and 1.00 x 10(-1) mol (.) L-1) decreases [Ca2+]i levels and cell spread area, and greater decreases are observed for the higher concentrations of La3+. Since [Ca2+], affects cytoskeleton and the adhesion properties of osteoclasts, our results seem to suggest that La3+ inhibit bone resorption by decreasing [Ca2+]i in rabbit mature osteoclasts.

语种: 英语
WOS记录号: WOS:000233064400015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59897
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Hebei Univ, Dept Chem, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
3.Capital Univ Med Sci, Sch Pharmaceut Sci, Beijing 100054, Peoples R China
4.Peking Univ, Stomatol Hosp, Dept Oral Pathol, Beijing 100081, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Zhang, JC,Zhang, TL,Xu, SJ,et al. Effect of lanthanum(III) on cytosolic free calcium in isolated rabbit mature osteoclasts[J]. JOURNAL OF RARE EARTHS,2005,23(5):580-583.
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