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No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart
Yang, Chengzhi1,2; Yang, Hui3; Wu, Jimin1,2; Meng, Zenghui1,2; Xing, Rui1,2; Tian, Aiju1,2; Tian, Xin3; Guo, Lijun1,2; Zhang, Youyi1,2; Nie, Guangjun3; Li, Zijian1,2
关键词Gold nanoparticles Heart Cardiac toxicity Cardiac remodeling
刊名TOXICOLOGY LETTERS
2013-10-24
DOI10.1016/j.toxlet.2013.07.018
222期:2页:197-203
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]CARDIAC-HYPERTROPHY ; PARTICLE-SIZE ; CYTOTOXICITY ; MODELS ; CELLS ; FIELD ; DRUG ; MICE
英文摘要

In this study, we investigated the cardiac biodistribution of polyethylene glycol (PEG)-coated AuNPs and their effects on cardiac function, structure and inflammation in both normal and cardiac remodeling mice. The model of cardiac remodeling was induced by subcutaneously injection of isoproterenol (ISO), a non-selective beta-adrenergic agonist, for 7 days. After AuNPs were injected intravenously in mice for 7 consecutive days, Au content in different organs was determined quantitatively by inductively coupled plasma mass spectrometry (ICP-MS), cardiac function and structure were measured by echocardiography, cardiac fibrosis was examined with picrosirius red staining, the morphology of cardiomyocytes was observed with hematoxylin and eosin (H & E) staining. The accumulation of AuNPs in hearts did not affect cardiac function or induce cardiac hypertrophy, cardiac fibrosis and cardiac inflammation under normal physiological condition. Cardiac AuNPs content was 6-fold higher in the cardiac remodeling mouse than normal mice. However, the increased accumulation of AuNPs in the heart did not aggravate ISO-induced cardiac hypertrophy, cardiac fibrosis or cardiac inflammation. These observations suggest that PEG-coated AuNPs possess excellent biocompatibility under both physiological and pathological conditions. Thus, AuNPs may be safe for cardiac patients and hold great promise for further development for various biomedical applications. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000324301900013
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59904
专题北京大学第三临床医学院
北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 3, Inst Vasc Med,Key Lab Cardiovasc Mol Biol & Regul, Minist Hlth,Key Lab Mol Cardiovasc Sci,Minist Edu, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Beijing Key Lab Cardiovasc Receptors Res, Inst Vasc Med, Beijing 100191, Peoples R China
3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Yang, Chengzhi,Yang, Hui,Wu, Jimin,et al. No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart[J]. TOXICOLOGY LETTERS,2013,222(2):197-203.
APA Yang, Chengzhi.,Yang, Hui.,Wu, Jimin.,Meng, Zenghui.,Xing, Rui.,...&Li, Zijian.(2013).No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart.TOXICOLOGY LETTERS,222(2),197-203.
MLA Yang, Chengzhi,et al."No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart".TOXICOLOGY LETTERS 222.2(2013):197-203.
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