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学科主题临床医学
Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis
Wang, Long-gang; Gu, Jin
关键词MicroRNA Serum Liver metastasis Colorectal cancer Early diagnosis
刊名CANCER EPIDEMIOLOGY
2012-02-01
DOI10.1016/j.canep.2011.05.002
36期:1页:E61-E67
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]Oncology ; Public, Environmental & Occupational Health
关键词[WOS]CIRCULATING MICRORNAS ; OVARIAN-CANCER ; BIOMARKERS ; SIGNATURES ; INJURY
英文摘要

Background: Colorectal cancer (CRC) metastasis occurs in various organs, most frequently in liver. Serological examination including tumor and biochemical markers for liver function evaluation is routinely performed, though its accuracy is not high. MicroRNAs (miRNAs) have been implicated in a variety of human diseases including cancer, and have many characteristics of an ideal biomarker most notably their inherent stability and resilience. Recently, several studies have indicated that circulating miRNAs hold much potential as novel noninvasive biomarkers for cancer and other disease processes. The objective of this study was to investigate the potential of serum miRNAs as novel biomarkers for CRC with liver metastasis. Methods: This study was divided into three phases: (I) 3 candidate serum miRNAs were detected by using real-time RT-PCR, corresponding 38 CRC patients with liver metastasis and 36 CRC patients without metastasis. (II) Marker validation by real-time RT-PCR on a similar cohort of age- and sex-matched CRC patients without (n = 20) and with liver metastasis (n = 20). (III) We examined the correlation between the expressions of candidate serum miRNAs with clinical parameters of CRC patients. Results: Serum miR-29a was significantly higher in colorectal liver metastasis (CRLM) patients than in CRC patients. This marker yielded a receiver operating characteristic curve area of 80.3%. At a cutoff value of 0.155, the sensitivity was 75% and the specificity was 75% in discriminating metastatic from non-metastatic patients. In addition, increased levels of miR-29a expression were also observed in colorectal tumors from CRLM patients compared with CRC patients. No significant difference was observed in the levels of serum miR-92a between metastatic and non-metastatic patients. Conclusions: These findings suggest that serum miR-29a has strong potential as a novel noninvasive biomarker for early detection of CRC with liver metastasis. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000300932600010
引用统计
被引频次:119[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59905
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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Wang, Long-gang,Gu, Jin. Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis[J]. CANCER EPIDEMIOLOGY,2012,36(1):E61-E67.
APA Wang, Long-gang,&Gu, Jin.(2012).Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis.CANCER EPIDEMIOLOGY,36(1),E61-E67.
MLA Wang, Long-gang,et al."Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis".CANCER EPIDEMIOLOGY 36.1(2012):E61-E67.
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